The No. 16 LSU Tigers will look to continue their dominance over the South Carolina Gamecocks when they meet in a key SEC matchup on Saturday. LSU has won the last seven meetings with South Carolina and is 19-2-1 all-time against the rivals. The Tigers (1-1), who were just 2-2 on the road last year, finished 10-3 overall in 2023. The Gamecocks (2-0), who were 5-2 at home, won just three of eight conference games a season ago.

Kickoff is set for noon ET. LSU holds a 19-2-1 series edge, and has won the last seven meetings. The Tigers are 6-point favorites in the latest LSU vs. South Carolina odds via SportsLine consensus, while the over/under for total points scored is 48. Before making any LSU vs. South Carolina picks, check out the college football predictions from the SportsLine Projection Model..

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen strong returns.

The model has set its sights on LSU vs. South Carolina. You can head to SportsLine to see its picks. Here are several college football betting lines for the spreadmoney line and over/under for the game: 

  • LSU vs. South Carolina spread: LSU -6
  • LSU vs. South Carolina over/under: 48 points
  • LSU vs. South Carolina money line: LSU -236, South Carolina +192
  • LSU: The Tigers have hit the game total over in 11 of their last 13 games (+8.80 units)
  • SC: The Gamecocks have hit the first-quarter money line in nine of their last 12 games (+11.40 units)
  • LSU vs. South Carolina picks: See picks at SportsLine

Why you should back LSU

Sophomore wide receiver Aaron Anderson is making his mark this season. He is coming off a five-catch, 63-yard performance in a 44-21 win over Nicholls last Saturday. In the 27-20 opening-game loss to Southern Cal, Anderson had five receptions for 64 yards and one score, including a long of 41 yards. For his career, Anderson has 22 receptions for 186 yards (8.5 average) and one touchdown.

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Senior defensive end Sai'vion Jones has been a beast on defense and leads the team with a pair of sacks for eight yards. They both came in the opener against USC. In two games, he has registered seven tackles, including four solo, with one forced fumble and one pass breakup. In four seasons with the Tigers, he has recorded 65 tackles, including 24 solo, with nine sacks, two forced fumbles and four pass breakups. See which team to pick here.

Why you should back South Carolina

Redshirt freshman quarterback LaNorris Sellers leads the Gamecocks offense. In two starts, he has completed 21 of 38 passes (55.3%) for 273 yards, two touchdowns and one interception with a rating of 127.7. Sellers has also carried 29 times for 64 yards (2.2 average) and one touchdown. In limited action a year ago, he completed all four of his passes for 86 yards and two touchdowns, while rushing five times for 51 yards and a score.

Senior running back Raheim Sanders also helps power the offense. He has carried 37 times for 142 yards (3.8 average) and two touchdowns. In the win at Kentucky, he carried 13 times for 54 yards (4.2 average) and one TD. Sanders is in his first season with the Gamecocks after spending three years at Arkansas. For his career, he has rushed 435 times for 2,372 yards (5.5 average) and 19 touchdowns. See which team to pick here.

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How to make LSU vs. South Carolina picks

SportsLine's model is leaning Over on the total, projecting 48 combined points. It also says one side of the spread hits more than 50% of the time. You can only get the pick at SportsLine..

So who wins LSU vs. South Carolina, and which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the LSU vs. South Carolina spread to jump on, all from the advanced model that is up over $2,000 on its FBS college football picks since its inception, and find out.