Big Ten rivals on opposite ends of the standings square off in Week 12 as the Purdue Boilermakers (1-8, 0-6) host the No. 4 Penn State Nittany Lions (8-1, 5-1) Saturday on Paramount+. The Boilermakers continue to have a disappointing 2024 campaign, most recently getting shut out by No. 2 Ohio State 45-0. Penn State's lone loss this season is to that same Buckeyes team, but the Nittany Lions have been dominant otherwise, upending Washington 35-6 their last time out to remain a strong College Football Playoff contender.
Kickoff from Ross-Ade Stadium in West Lafayette, Ind. is at 3:30 p.m. ET. The Nittany Lions are 29.5-point favorites in the latest Purdue vs. Penn State odds, while the over/under for total points scored is 51.5 via SportsLine consensus. Before making any Penn State vs. Purdue picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.
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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a strong 18-12 on all top-rated picks over the past seven weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.
Now, the model has dialed in on Purdue vs. Penn State and just revealed its coveted betting picks and predictions. You can head to SportsLine now to see the model's picks. Here are the college football odds for the Penn State vs. Purdue matchup:
- Purdue vs. Penn State spread: Penn State -29.5
- Purdue vs. Penn State over/under: 51.5 points
- Purdue vs. Penn State money line: Penn State -9091, Purdue +1988
- Purdue vs. Penn State picks: See picks at SportsLine
- Purdue vs. Penn State streaming: Paramount+ (Get 7 days free)
Why Purdue can cover
While the Boilermakers haven't won a game since a 49-0 victory against Indiana State in Week 1, not all of their games have been blow-out losses. In-conference games against Illinois and Washington both went to overtime, showing that Purdue has the capacity to get into the end zone and keep games close.
When these teams last played each other in 2022, the Boilermakers rallied in the second half in West Lafayette and were only narrowly beaten 35-31. It isn't clear yet who will start under center, but Ryan Browne -- who threw for 297 yards with three touchdowns and no interceptions against Illinois -- would give Purdue great a shot at covering the spread on Saturday if he plays up to his potential. See picks at SportsLine.
Why Penn State can cover
The Nittany Lions have covered the spread in two of their last three games, both of which were victories. They are also 5-1-0 ATS in Big Ten play as well as 2-1-0 ATS in road games this season as they visit West Lafayette for the first time since 2022.
All eyes will be on starting quarterback Drew Allar to keep rolling after he completed 71.4% of his passes against Washington in Week 11. Allar has connected regularly with Harrison Wallace III while Kaytron Allen has propelled the ground game, and all three should be in fine form against the worst defense in the Big Ten on Saturday. See picks at SportsLine.
How to make Penn State vs. Purdue picks
SportsLine's model is going Under on the total, projecting 50 combined points. It also says one side of the spread hits in well over 50% of simulations. You can see the model's pick at SportsLine.
So who wins Penn State vs. Purdue, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up well over $2,000 on top-rated spread picks since its inception, and find out, and don't forget to stream the game on Paramount+.