The No. 23 Clemson Tigers (6-2) will try to avoid suffering consecutive upset losses when they face the Virginia Tech Hokies (5-4) on Saturday afternoon. Clemson had its six-game winning streak snapped in a 33-21 loss to Louisville last week, falling out of the College Football Playoff picture. The Tigers are also now sitting behind No. 4 Miami (FL) and No. 13 SMU atop the ACC standings. Virginia Tech is hoping to bounce back from a loss of its own after falling to Syracuse in overtime last week. 

Kickoff is set for 3:30 p.m. ET on Saturday at Lane Stadium/Worsham Field. Clemson is favored by 6.5 points in the latest Virginia Tech vs. Clemson odds, while the over/under is 53 points, per SportsLine consensus. Before entering any Clemson vs. Virginia Tech picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 18-9 on all top-rated picks over the past six weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

The model has set its sights on Clemson vs. Virginia Tech. You can head to SportsLine to see its picks. Here are several college football betting lines for the game:

  • Virginia Tech vs. Clemson spread: Clemson -6.5
  • Virginia Tech vs. Clemson over/under: 53 points
  • Virginia Tech vs. Clemson money line: Clemson -234, Virginia Tech +188
  • Virginia Tech vs. Clemson picks: See picks here
  • Virginia Tech vs. Clemson streaming: FuboTV (Try for free)

Why Virginia Tech can cover

Virginia Tech is one of the best four-loss teams in college football, as all four of its losses have come by one score. The Hokies are coming off their second overtime loss of the year, as they blew a 21-3 lead in their 38-31 loss at Syracuse. They were without starting quarterback Kyron Drones, as backup Collin Schlee had 206 yards and a touchdown in relief. 

Drones, who was dealing with a lower body injury, is questionable to return this week. Lead running back Bhayshul Tuten was also out due to an ankle injury, and he is also questionable to play on Saturday. Virginia Tech has won six of its last eight home games and has covered the spread in four of its last five games overall. See which team to pick here. 

Why Clemson can cover

Clemson likely had its College Football Playoff hopes go up in smoke last week, but the Tigers have been impressive outside of their two losses. They have won six games by at least 16 points, covering the spread in four of those games. Junior quarterback Cade Klubnik has impressive numbers, racking up 2,064 passing yards, 21 touchdowns and just three interceptions. 

He has also rushed for 270 yards and four touchdowns, so Virginia Tech's defense will have its hands full. Senior running back Phil Mafah has 853 rushing yards and eight touchdowns, averaging 6.3 yards per carry. The Tigers have won six straight meetings with the Hokies, covering the spread in five of those games. See which team to pick here. 

How to make Virginia Tech vs. Clemson picks

The model has simulated Clemson vs. Virginia Tech 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You can only see the pick at SportsLine.

So who wins Virginia Tech vs. Clemson, and which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the Clemson vs. Virginia Tech spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.