Stefanic was removed from Friday's game versus the Astros due to right calf tightness, Rhett Bollinger of MLB.com reports.
Manager Ron Washington said after Friday's loss that Stefanic's injury is relatively minor, so an extended absence is unlikely. If he and Brandon Drury (hamstring) are both unable to play Saturday, Jack Lopez would be the favorite to start at second base.
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Angels' Michael Stefanic: Sitting out Saturday
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