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Wetherholt will start at second base and bat leadoff in Thursday's opener versus the Rays.

The Cardinals will not ease Wetherholt into his major-league debut, putting him atop their batting order. The team's other potential option in the leadoff spot, Masyn Winn, will hit cleanup. Wetherholt earned a spot on St. Louis' Opening Day roster by collecting a .386 on-base percentage with two home runs and two stolen bases during Grapefruit League action.

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