The Diamondbacks selected Hughes' contract from Triple-A Reno on Saturday.
With Ryne Nelson (shoulder) headed for the injured list, Hughes will rejoin the active roster in order to give the Diamondbacks some additional depth in their bullpen. The 28-year-old lefty hasn't found much success in the big leagues with a 10.29 ERA across 14 innings, though he's turned in a 2.08 ERA and 1.20 WHIP across 21.2 frames at Triple-A since making his last MLB appearance. Andrew Knizner was DFA'd to create space for Hughes on the 40-man roster.