Wilkinson was optioned to Triple-A Sacramento on Monday, Shayna Rubin of the San Francisco Chronicle reports.
Wilkinson was tagged for four runs on seven hits while striking out a pair in Sunday's start against Boston, and the club has elected to bring up a fresh arm rather than give him another opportunity in the rotation. The Giants promoted Anthony Molina to the big leagues Monday, who could be in line to start one of Saturday's games against Arizona.