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Manzardo started at first base and went 1-for-4 with a two-run home run in Thursday's 6-1 win over the White Sox.
Manzardo, who was recently moved into the cleanup spot, went yard in the first inning for what proved to be the game-winning hit. It was his fourth home run through 12 games, and Manzardo's 11 RBI leads the club. He made only six starts at first base in 2024 compared to 40 at DH, denying him 1B eligibility in more restrictive fantasy formats, and Thursday's game was his third start at the position in 2025. The Guardians' desire to manage the workload of 39-year-old Carlos Santana, Cleveland's primary first baseman, should result in Manzardo gaining some extra positional flexibility later this season.
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