Manzardo started as the designated hitter and went 0-for-4 with four strikeouts in Friday's 5-1 loss to the Mariners.
Manzardo has been stuck at DH the first two games of the season, with both starts coming against right-handed pitchers. The right-handed-hitting Rhys Hoskins started at first in both games. There was some thought that Manzardo would see more time at first base this season with Carlos Santana no longer on the team, but those plans apparently changed when the Guardians signed Hoskins after spring training started.