White Sox starting pitcher Jose Quintana was hit hard in his season debut Friday night against the Mariners.

Quintana served up a solo home run to Franklin Gutierrez in the opening frame, but settled down until the fifth inning where he was tagged for five runs, including a two-run double to Gutierrez again. The left-hander was charged with six runs on eight hits in four innings of work and did not factor in the decision. He struck out three and walked two in 77 pitches.

Quintana is slated to take the mound again Thursday at Washington. The 23-year-old has yet to face the Nationals in his career but went 1-0 with a 0.42 ERA and a 0.98 WHIP in three interleague starts last season.