Citing a sore right leg muscle, the Marlins kept second baseman Dee Gordon out of Friday's lineup, reports MLB.com.
"Precautionary to make sure it doesn't lead into something," general manager Dan Jennings said.
In his first 28 games, Gordon has amassed 52 hits. Second baseman Donovan Solano will start at second base and bat eighth.
The Marlins are the underdogs (+115) at San Francisco on Friday.