The Orioles placed Urias on the 10-day injured list Sunday due to a right ankle sprain.
The 30-year-old suffered the injury during Saturday's contest in Colorado and will be sidelined for at least the next week and a half. Coby Mayo, who is one of Baltimore's top prospects, was recalled from Triple-A Norfolk in a corresponding move Sunday and should see some run at third base while Urias is sidelined.