Rodriguez (knee) will begin a rehab assignment with one of the Red Sox's affiliates as early as Saturday, the Boston Globe reports.

On Monday, Rodriguez completed a 55-pitch simulated game at the Red Sox's facility in Fort Myers, Fla., which has seemingly paved the way for the next step in the process. Because a return to the big league rotation is likely the desired result, he could log a few starts with an increasing pitch count with that aim in mind.