Holton will serve as the Tigers' opening pitcher during Monday's game against the Padres.
Holton has been an important member of Detroit's bullpen this season, posting a 2.44 ERA and 0.83 WHIP across 77.1 innings. Most of his appearances have lasted more than one inning, and he was able to reach three frames as recently as Aug. 17. Once the 28-year-old lefty exits Monday's contest, Ty Madden is expected to pitch in bulk relief.