The Twins placed Ryan on the 15-day injured list Friday with a Grade 2 right teres major strain, Do-Hyoung Park of MLB.com reports.
Manager Rocco Baldelli said Friday that Ryan's recovery will take "weeks to months," so the right-hander's season could be over. The injury is a massive blow to Ryan's fantasy managers and to a Twins club fighting for a playoff spot. Louie Varland will be recalled from Triple-A St. Paul to start the second game of Saturday's doubleheader against the Guardians, and he might now be needed in the big-league rotation indefinitely.