Murakami is out of the lineup for Tuesday's game against the Orioles.
The 26-year-old started the White Sox's first 10 games of the season but will take a seat after going 2-for-16 in the past five contests. Murakami has showcased his power upside already with four homers, but his swing-and-miss propensity has also been evident in the form of a 31.0 percent strikeout rate. Lenyn Sosa is taking over at first base Tuesday for Chicago.