Sampson sustained a knee injury in the first quarter of Sunday's game against the Jaguars and is considered questionable to return, Mary Kay Cabot of The Cleveland Plain Dealer reports.
Sampson didn't receive any touches on offense but returned two kickoffs for 64 yards before exiting the contest. The second-year running back headed to the locker room and will be evaluated further before the Browns decide whether he'll be able to return to the game.