Ifedi suffered a hand injury during Saturday's preseason game against Minnesota and has been ruled out from returning, Daniel Oyefusi of ESPN.com reports.
Ifedi signed with the Browns in April after spending part of last season on the team's practice squad. He had been on the outside looking in for a spot on the 53-man roster prior to getting hurt Saturday, and the injury could spell an end to his chances if it causes him to miss additional time.