The Chargers elevated Uiagalelei from the practice squad to the active roster Saturday ahead of Sunday's game against the Broncos.
With Justin Herbert (left hand/rest) set to sit for Week 18, Uiagalelei will get his first elevation of the season to back up starting quarterback Trey Lance. If Lance must exit the contest for any reason, Uiagalelei will see his first NFL regular-season reps in Sunday's game.