The big story heading into Week 4 is the loss of Saquon Barkley to a high-ankle sprain, an injury that will likely keep him out for at least a month, if not quite a bit longer. If that were the only question Fantasy players were dealing with, of course, it would be pretty easy to navigate.

However, the running back position looks like even more of a minefield as we near the quarterway mark as it ever has, with fully 12 of the top-20 in ADP entering the week with at least some kind of questions about their value.

Those questions range from easy to answer — "Can Alvin Kamara and Christian McCaffrey continue to produce with backup quarterbacks?" (YES) — to a bit thornier — "Are Josh Jacobs, Aaron Jones and Chris Carson looking at committee situations?" (MAYBE!) — to legitimately worrisome — "Does Damien Williams have a chance to reclaim his role?" (DOESN'T LOOK GOOD!)

We'll be going through some of the biggest questions Fantasy players are facing heading into Week 4 here, with Jamey Eisenberg, Dave Richard and Heath Cummings providing their answers. However, make sure you check out what else we've got as we preview Week 4, including:

Whether you're 3-0 or 0-3 or somewhere in between, we've got everything you need to pull off a win this week. Here's what our experts expect for Week 4: 

1. What are your expectations for Wayne Gallman in Saquon Barkley's absence? 

  • Jamey Eisenberg: Gallman is a mediocre talent in a good situation. If he is the main guy for the Giants — assuming no one significant is added with Barkley hurt — then I would expect about 15 touches per week. For his career, Gallman has six games with double digits in carries, with most of them coming in his rookie campaign in 2017, before Barkley was in the NFL. In four of those games, he scored at least 11 PPR points. In three of those games, he also had at least five catches. So he might prove to be a competent replacement option. I'd consider him a weekly flex, with the chance to be a starter depending on the matchups.
  • Dave Richard: I think he'll be average. The Giants figure to add another running back to lighten his load, presumably someone a little more powerful than Gallman. Maybe he gets 15 touches per game. Maybe he catches more than three balls per game. I'm not excited about him. 
  • Heath Cummings: I have him projected for 14 touches, 75 yards and .75 touchdowns this week against Washington. That makes him a mid-range No. 2 running back. 

2. If you were trying to buy low on a running back to replace Barkley, who would be your top pick?

  • Jamey: I think you can get David Montgomery relatively cheap, and his workload should improve. Matt Nagy should figure that out, right? He's the Bears best offensive player, and I'd love to see him get 20-plus total touches a week on a consistent basis. If that happens, he could be a top-15 Fantasy running back, regardless of format.
  • Dave: I'll start with Chris Carson, who I think will continue to have a role in Seattle. I'll also see what Josh Jacobs and Montgomery would cost me in a deal. And two more rookies: Miles Sanders and Devin Singletary. I'd expect Sanders to get on track here soon and Singletary to return. Wouldn't mind getting them with the long haul in mind. 
  • Heath: First off, there's no replacing Barkley. But I really love the usage for Leonard Fournette and think he's been pretty unlucky to not reach the end zone so far. I still expect him to be a top-12 pick rest of season.

3. Which early-round pick are you most worried about right now?

  • Jamey: JuJu Smith-Schuster scares me with Ben Roethlisberger (elbow) hurt. He's not going to get the target share we were hoping for, and the quality of targets will obviously not be the same. He's still going to be a starting Fantasy receiver, but he's not going to deliver on his preseason rankings with Mason Rudolph throwing him passes.
  • Dave: Uh, Saquon. What if the Giants end up losing a bunch and they opt not to bring him back by Week 12?! What if he just never gets himself right after the ankle sprain? 
  • Heath: I'm worried about Joe Mixon, even though he's coming off his best game. As a team, the Bengals own the worst rushing average in the league and Zac Taylor seems to be trending towards one of the more pass-heavy offenses. 

4. Which slow-starting star do you expect to turn it around in Week 4?

  • Jamey: Davante Adams will go off against the Eagles on Thursday night. He might not have the exact game Mike Evans just had in Week 3 against the Giants, but it might not be far off. Buy him now if you're able to get him cheap given his slow start.
  • Dave: Adams better turn it around in Week 4. He's playing a weak and depleted Eagles pass defense on a short week at Lambeau. If he can't find the end zone, then I think Fantasy managers will have some legit gripes. 
  • Heath: Fournette would be my first choice, but I'll also say Robert Woods. It's an outstanding matchup against Tampa Bay and for the most part Woods' targets have still been there. 

5. Who is the top tight end you would add for Week 4? And beyond?

  • Jamey: Will Dissly and it's not close. He has the best matchup of any tight end against the Cardinals, who have allowed the first three tight ends they've faced to score 25 PPR points. And Dissly has already played well in two of three games this year. 
  • Dave: Dissly should be the unanimous answer. Great matchup in Week 4, great chance to be a regular contributor for the Seahawks, especially if the coaches lose faith in their run game because of continued disappointments (which I would not hope for if I'm trading for Carson). 
  • Heath: It's gotta be Dissly for Week 4, if only because he gets the Arizona Cardinals this week. They've allowed the No. 1 TE in non-PPR each of the first three weeks of the season. But even independent of the matchup, Dissly has now put up 20-280-5 in his first six-plus NFL games. He may just be a top-12 tight end regardless of matchup.

6. What is your top streaming DST option for Week 3?

  • Jamey: If you can't get the Chargers DST (at MIA), then go get the Steelers DST for the matchup against the Bengals. Remember, it's Andy Dalton in a prime-time game, which is always a favorable situation for the opposing defense.
  • Dave: The Steelers, home against the Bengals. I think this is a way better unit with Minkah Fitzpatrick at safety.
  • Heath: I'll take the Colts at home against the Raiders. The Broncos against Jacksonville aren't a bad choice either.

7. Which players aren't worth holding onto during the bye week for the 49ers and Jets? 

  • Jamey: The only players for the 49ers and Jets that I'm 100% holding onto are George Kittle, Le'Veon Bell, Tevin Coleman and Matt Breida. None of the quarterbacks or receivers are must-holds, and I expect Raheem Mostert to lose value when Coleman is back.
  • Dave: Hold the obvious ones: Bell, Kittle, Coleman, Breida. I can't see people racing to pick up Robby Anderson or Jamison Crowder if they're dropped in 10- and 12-team leagues. Same with any 49ers receiver or with Jimmy Garoppolo.
  • Heath: Bell is the only Jet I'm holding in a standard league. There are just too many good speculative options to be holding the receivers or Chris Herndon. The 49ers are more complicated but I don't imagine I'd hold any of their receivers in a league with only five bench spots. I'm also not holding Garoppolo in a one-quarterback league.