The Patriots ruled out Henderson for Wednesday's season opener versus the Seahawks, Evan Lazar of the Patriots' official site reports.
Henderson's absence for the opener hardly comes as a surprise, as an ankle injury has kept him from practicing in any capacity since Aug. 24. With the second-year RB sidelined, Rhamondre Stevenson will handle the bulk of snaps and touches out of the backfield. Corey Kiner is the only other healthy back on the depth chart, but the Patriots will likely elevate one or both of Lan Larison and Hassan Haskins from the practice squad.