Rams quarterback Sam Bradford faces a difficult opening matchup: the Cardinals allowed an average of 12.5 Fantasy points to opposing QBs last year, tied for fewest in the NFL.

Bradford threw a pair of touchdowns in each meeting with Arizona last year, but completed less than 50 percent of his throws and averaged 173 yards passing. He's got better weapons this year, a stronger offensive line, and for the first time in his career he didn't have to learn a new system. The fourth-year pro put together an encouraging preseason, averaging a whopping 10.2 yards per attempt.

Still, Bradford is only an option in two-QB leagues this week.