Mayowa (neck) has been ruled out for Sunday's game against the 49ers.
Mayowa was inactive for Week 3, but he appeared on track to return in Week 4 after logging a full practice Wednesday. However, the 30-year-old defensive end has now suffered a setback and will be inactive for the second straight week. Darrell Taylor and Alton Robinson both saw increased snaps during Mayowa's absence against the Vikings and should garner similar workloads against the 49ers.