Vikings head coach Kevin O'Connell said Addison (ankle) won't take part in Wednesday's practice, Ben Goessling of the Minneapolis Star Tribune reports.
Instead, Addison will focus on treatment of his right ankle to begin Week 2 prep after injuring it during this past Sunday's win at the Giants. O'Connell told Dane Mizutani of the St. Paul Pioneer Press on Monday that he was "hopeful" Addison will be able to play Sunday against the 49ers, but the receiver may have to mix into drills Thursday and/or Friday in order for the Vikings to feel comfortable making him active. Brandon Powell and Jalen Nailor are next up for reps at wide receiver behind top option Justin Jefferson in Minnesota's offense.