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Carson Wentz QB | MIN
Vikings' Carson Wentz: Returns to Sunday's game
Wentz returned to Sunday's game against the Browns for the third quarter after having exited with a left shoulder injury in the second quarter.
Wentz will thus look to help the Vikings overcome a 10-7 halftime deficit, with Max Brosmer on hand should the veteran signal-caller suffer any setbacks with his (non-throwing) shoulder.
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Bucky Irving RB | TB
Buccaneers' Bucky Irving: Likely to remain out through Week 6
Irving (foot/shoulder), who has been ruled out for Sunday's game against the Seahawks, is likely to remain sidelined for the Buccaneers' Week 6 contest versus the 49ers on Oct. 12, Adam Schefter of ESPN reports.
In the aftermath of the Buccaneers' Week 4 loss to the Eagles, Irving was diagnosed with a left foot sprain, which confined him to a walking boot and kept him from practicing Wednesday through Friday before Tampa Bay confirmed he wouldn't play this weekend. In addition, Irving was listed on the Buccaneers' official injury report with a shoulder issue, which Schefter relays is a subluxation that is considered the worse of the running back's two health concerns. The Buccaneers will likely wait and see what, if any, practice activity Irving is able to take part in during the upcoming week before deciding on his status for the matchup with the 49ers, but fantasy managers should brace for a two-game absence for the second-year tailback. While Irving is out, Rachaad White is expected to see the majority of the carries out of the Tampa Bay backfield in addition to serving as the team's top pass-catching back, though reserves Sean Tucker and Josh Williams are also expected to see expanded profiles in the ground attack.
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Shedeur Sanders QB | CLE
Browns' Shedeur Sanders: Still expected to play in 2025
Sanders (coach's decision), who is inactive as the Browns' emergency third quarterback for Sunday's game against the Vikings in London, is expected to play at some point during his rookie season once the coaching staff deems him ready, Ian Rapoport of NFL Network reports.
Though Cleveland has elected to bench Joe Flacco after he led the team to a 1-3 start through the first four weeks of the season, Flacco will suit up as the No. 2 quarterback ahead of Sanders while the Browns turn to rookie third-round pick Dillon Gabriel to make his first NFL start. Gabriel had been serving as Flacco's top backup in each of the previous four contests, and the 24-year-old has already made a strong impression on the coaching staff in practices and in two spot appearances late in blowouts due to his ability to get the ball out quickly and process the defense. That being said, the 5-foot-11 Gabriel's lack of ideal size and physical tools could work against him in his development as an NFL-level starter, so if he's unable to find much success in his first few extended appearances, the Browns could eventually turn the offense over to Sanders. Rapoport notes that because the Browns designed their Week 5 game plan with Gabriel's aptitude as a runner in mind, Cleveland was reluctant to appoint Sanders to the No. 2 role right away as part of a game plan that wouldn't be tailored to his strengths. Ideally, if and when the Browns decide to have Sanders play, he'll get a full week of practice with the first-team offense in advance and will have a game plan built specifically for his skill set.
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Taysom Hill QB | NO
Saints' Taysom Hill: Set to fill gadget role in Week 5
Hill (knee) remains listed as questionable for Sunday's game against the Giants, but he's expected to be available for the contest in his typical gadget role, Jeff Duncan of The Athletic reports.
Hill's availability won't be confirmed until the Saints release their inactive list 90 minutes prior to Sunday's 1 p.m. ET kickoff, but the team's decision to activate him from the reserve/PUP list Saturday had already suggested that he was on track to make his 2025 debut this weekend. Duncan notes that the Saints plan to list Hill as their top backup quarterback behind starting Spencer Rattler, likely indicating that rookie second-round pick Tyler Shough will be inactive as the team's emergency third quarterback. Though the Saints may want to ease Hill into the mix with a light workload coming off the torn ACL he sustained last December, the 35-year-old projects to see some carries Sunday and potentially even some looks in the passing game when he lines up as a tight end.
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Taylor Decker OT | DET
Lions' Taylor Decker: Trending toward sitting Sunday
The Lions downgraded Decker (shoulder) from questionable to doubtful for Sunday's game against the Bengals.
Decker was unable to practice at any point this week, and though the Lions initially held out some hope that he might be able to play through the shoulder injury Sunday, the team is now leaning toward holding him out. The Lions are likely to turn to 2024 fourth-round pick Giovanni Manu to make his first career start at left tackle in Decker's stead.
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Rachaad White RB | WAS
Buccaneers' Rachaad White: Likely to lead ground attack
White is expected to receive the "vast majority" of carries in Sunday's game against the Seahawks while starter Bucky Irving (foot/shoulder) is sidelined for the contest, Ian Rapoport of NFL Network reports.
Through the first four weeks of the season, White has filled a change-of-pace role behind Irving, but the former should have the opportunity to see his largest workload to date while the Buccaneers are without their top running back. Though Pelissero notes that the Buccaneers also have a plan to keep Sean Tucker involved in the ground attack and expect undrafted rookie Josh Williams to get some opportunities out of the backfield as well, White looks to be the most appealing fantasy option of Tampa Bay's three healthy running backs. In addition to being expected to lead the way in carries, White should also dominate the work on passing downs.
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Ben Yurosek TE | MIN
Vikings' Ben Yurosek: Not available Sunday
Yurosek (knee) is inactive for Sunday's game against the Browns in London.
Yurosek will miss his second straight game due to the knee injury he sustained in the Vikings' Week 3 win over the Bengals. The undrafted rookie tight end has held a minor role on offense over his three appearances this season, but his absence will be more noteworthy on special teams, where he's a regular part of the Vikings' coverage units.
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C.J. Ham FB | MIN
Vikings' C.J. Ham: Debuting in Week 5
Ham (knee) is active for Sunday's game against the Browns in London.
Ham was sidelined for the Vikings' first four games of the season, but he returned to practice this week as a full participant and was activated from injured reserve Saturday, so the writing was on the wall for him to make his 2025 debut Sunday. The 32-year-old is the lone fullback on the Vikings' roster, but in past seasons, he's typically been a part-time contributor on offense and has served mainly as a blocker. Ham is also a key part of Minnesota's special-teams units.
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Brock Bowers TE | LV
Raiders' Brock Bowers: Likely to sit out with PCL injury
Bowers, who is officially listed as questionable for Sunday's game against the Colts, has been playing through a PCL injury and bone bruise on his knee that has affected his performance, Adam Schefter of ESPN reports.
The report notes that doctors have indicated rest is the tight end's path to moving past the issue, an approach that Schefter suggests Bowers has reluctant to take thus far. On Saturday, Ian Rapoport of NFL Network reported that Bowers is trending toward not playing Sunday, while Schefter relayed that fellow tight end Michael Mayer (concussion) is also is line to sit out Week 5. In the event that both players are made inactive ahead of the 1 p.m. ET kickoff, Ian Thomas, Carter Runyon and Albert Okwuegbunam would be the team's available options at tight end.