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Khadarel Hodge WR | SF
49ers' KhaDarel Hodge: Promoted to active roster
The 49ers signed Hodge from the practice squad to the active roster Wednesday, Jeremy Fowler of ESPN.com reports.
Hodge was on the field for the 27-7 win over the Rams in Week 1. He is now back on the active roster for the Week 2 meeting with Miami, though he will likely spend most of his time on special teams.
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Nick Muse TE | ATL
Falcons' Nick Muse: Joins Falcons' active roster
Muse was signed to the active roster by Atlanta on Wednesday, William McFadden of the Falcons' official site reports.
Muse was recently elevated from the practice squad ahead of Sunday's 20-13 loss to Pittsburgh. After reverting to the practice squad Monday, the 27-year-old is now back on the 53-man roster. However, with Kyle Pitts, Charlie Woerner and Austin Hooper healthy, Muse will presumably continue to spend most of his time on special teams.
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Henry To'oTo'o LB | HOU
Texans' Henry To'oTo'o: Expected to miss more than four games
To'oTo'o (shoulder) is expected to miss more than four games, Mike Garafolo of NFL Network reports.
To'oTo'o landed on injured reserve Tuesday, which will keep him off the field for at least four games. However, according to Garafolo, the 25-year-old is expected to be out "longer," possibly missing up to eight weeks. To'oTo'o finished the 2025 campaign by amassing 95 total tackles and 2.5 sacks in 17 regular-season games.
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Michael Penix Jr. QB | ATL
Falcons' Michael Penix: Could play in Week 2
Penix (knee) was listed as a full participant in Wednesday's practice, Daniel Flick of The Atlanta Journal-Constitution reports.
Penix practiced fully from Wednesday through Friday last week and ultimately was inactive for Week 1, so he is not a lock to suit up for Week 2 just yet. However -- per the same source above -- he shared the first-team work with Cooper Rush on Wednesday, and -- via Marc Raimondi of ESPN.com -- Penix himself indicated he could take the field Sunday. It likely will not be known for a day or two who will start at quarterback for the Falcons in Week 2, but at the least Penix is in the mix.
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Zay Flowers WR | BAL
Ravens' Zay Flowers: Misses Wednesday's practice
Flowers (hamstring) was listed as a non-participant for Wednesday's practice.
Flowers aggravated a hamstring issue from the preseason during Sunday's win over the Colts. He had piled up a career-high 150 yards in the first half but did not return to action after the aggravation. Coach Jesse Minter called Flowers day-to-day earlier Wednesday. Flowers' next chance to practice will come Thursday, but at this stage his status for Week 2 is murky at best. Baltimore's receiving depth is being tested early as rookie Ja'Kobi Lane (wrist) is on injured reserve after undergoing surgery.
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Alec Pierce WR | IND
Colts' Alec Pierce: Practices fully Wednesday
Pierce (hand/wrist) fully participated in Wednesday's practice, Kevin Bowen of 107.5 The Fan Indianapolis reports.
Pierce was listed on the injury report with the heel injury he dealt with previously and not the wrist issue he picked up in Week 1, but neither prevented him from getting in a full session Wednesday. As such, consider Pierce in the clear for his team's Week 2 matchup with the Chiefs.
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Aaron Jones RB | MIN
Vikings' Aaron Jones: Bigger role on tap
Jones projects to have a bigger role in the coming weeks with Jordan Mason (thumb) on short-term injured reserve, Alec Lewis of The Athletic reports.
Jones impressed in Week 1 with a touchdown but played only 30 snaps, as Jordan Mason ate up a decent amount of reps as well. With Mason out for at least four weeks, Jones projects to lead the backfield while DeeJay Dallas, Demond Claiborne and Jerome Ford serve as depth options.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Good to go for Week 2
Kamara (knee) was a full participant in Wednesday's practice, Katherine Terrell of ESPN.com reports.
New Orleans' backfield will get a boost in Week 2 with Kamara back in the mix after missing the season opener with a knee injury. The veteran injured his knee late in the preseason and returned to practice ahead of Week 1 but was not yet ready to give it a go. His full practice Wednesday points to Kamara being available for Sunday's game against the Ravens.
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TreVeyon Henderson RB | NE
Patriots' TreVeyon Henderson: Full practice Wednesday
Henderson (ankle) was a full participant in Wednesday's practice.
This is a big development for Henderson after his ankle injury kept him out of the season opener. He was a full-go in Wednesday's session, which bodes well for him making his 2026 debut Sunday against the Steelers. The Patriots struggled to run the ball in his absence against the Seahawks, recording just 3.9 yards per carry as a team. Rhamondre Stevenson and Corey Kiner mustered just 62 yards on 24 carries.
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RJ Harvey RB | DEN
Broncos' RJ Harvey: Dealing with hamstring issue
Harvey (hamstring) was estimated as a non-participant at Wednesday's practice, Chris Tomasson of the Denver Gazette reports.
Since Denver played Monday night, Wednesday was not an official practice. However, Harvey would not have participated if there had been a practice, according to Tomasson. The second-year running back is dealing with a hamstring issue that will be monitored throughout the remainder of the week. This is particularly notable with Denver on a short week. If Harvey is limited or unable to play Sunday against the Jaguars, it would open more opportunities for J.K. Dobbins and Jonah Coleman.