Red Sox starter Joe Kelly (1-0) held the Yankees to one run on one hit in seven innings Saturday to earn the win in Boston's 8-4 victory.
He retired his final 17 batters and left the game with an 8-1 lead.
Kelly, who had come off the 15-day disabled list before game time, struck out eight and walked two while throwing 93 pitches.
"I'm just happy I came out and made it through the game healthy," Kelly said. "That's not what I expected. I went out there and just tried to attack the zone. It was a long game last night. ... I knew that we were kind of thin in the bullpen, so I just tried to make quick outs."
Kelly is scheduled to make his next start Thursday against the Orioles.