White Sox vs. Guardians odds, line, prediction, start time: 2025 MLB Picks, April 10 bets from proven model

The Cleveland Guardians (5-6) and the Chicago White Sox (2-9) are set to battle in an AL Central mantinee on Thursday. The Guardians are going for the sweep in this contest, securing wins in Games 1 and 2. Cleveland defeated Chicago 3-2 in Wednesday's contest. As for the White Sox, they have dropped seven straight games. Jonathan Cannon (0-1, 3.12 ERA) is starting for Chicago, while Gavin Williams (0-0, 4.50 ERA) is on the mound for Cleveland.

First pitch from the Progressive Field is set for 1:10 p.m. ET. Cleveland is a -253 favorite on the money line (risk $253 to win $100) in the latest Guardians vs. White Sox odds from SportsLine consensus, while the total number of runs Vegas thinks will be scored, or the over/under, is 7. Before making any White Sox vs. Guardians picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters the 2025 MLB season on a 32-17 roll on top-rated run-line betting picks (+699) that dates back to 2023. Anybody following at sportsbooks and on betting apps could have seen strong returns.

Now, the model has set its sights on Guardians vs. White Sox and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Guardians vs. White Sox:

• Guardians vs. White Sox money line: Cleveland -245, Chicago +200 at FanDuel Sportsbook
• Guardians vs. White Sox over/under: 7 runs
• Guardians vs. White Sox run line: Cleveland -1.5 (-115)
• Guardians vs. White Sox picks: See picks at SportsLine
• Guardians vs. White Sox streaming: FuboTV (Try for free)

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Why the Guardians can cover

Third baseman Jose Ramirez has excellent bat control with the power to create extra base hits. This season, he's hitting .281 with four home runs and six RBI. Ramirez has compiled nine total hits, two doubles, and six runs scored. In Tuesday's win over the White Sox, he went 1-of-4 with a base hit. 

Left fielder Steven Kwan provides this team with a consistent contact hitter. Kwan uses his bat speed to get on base with ease, leading the team in batting average (.300) to go along with one home run, three RBI, and 12 hits. On April 5 against the Angels, Kwan was 2-of-3 with one run scored. See which team to back at SportsLine.

Why the White Sox can cover

Second baseman Brooks Baldwin is a switch hitter with good awareness defensively. Baldwin is hitting .250 with one home run, five RBI, and a .634 OPS. He's recorded a hit in four of his six outings this season. In the April 5 win over the Tigers, Baldwin has 1-of-4 with a base hit. 

Thus far into the season, the White Sox are 3-2 against the spread as the home team. They have also gone 4-3-1 against the spread in division games. In addition, Chicago has a 7-4 run line record in 2025. This group is looking to cover the run line for the third consecutive game. See which team to back at SportsLine. 

How to make Guardians vs. White Sox picks

SportsLine's model is leaning Over on the total, projecting 8.7 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model's MLB picks. 

So who wins Guardians vs. White Sox, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.

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