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We've got another exciting Western Conference matchup on Wednesday's NBA schedule as the Los Angeles Lakers will visit the San Antonio Spurs. San Antonio is 10-8 overall and 8-3 at home, while Los Angeles is 10-7 overall and 3-5 on the road. The Lakers have won seven of the last eight meetings, including a 120-115 victory on Nov. 15. The Spurs are 10-8 against the spread (ATS) in the 2024-25 NBA season, while the Lakers are 7-10 versus the line.

Tipoff is at 8:30 p.m. ET at Frost Bank Center in San Antonio. Los Angeles is favored by 2.5 points in the latest Spurs vs. Lakers odds, per SportsLine consensus, and the over/under is 228 points. Before entering any Lakers vs. Spurs picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 6 of the 2024-25 NBA season on a sizzling 114-76 roll on all top-rated NBA picks dating back to last season, returning more than $3,000. Anyone following at sportsbooks and on betting apps has seen huge returns.

The model has set its sights on Los Angeles vs. San Antonio. You can head to SportsLine to see its picks. Here are several NBA betting lines for Lakers vs. Spurs:

  • Spurs vs. Lakers spread: Spurs +2.5 
  • Spurs vs. Lakers over/under: 228 points
  • Spurs vs. Lakers money line: Spurs: +121, Lakers: -144
  • Spurs vs. Lakers picks: See picks at SportsLine
  • Spurs vs. Lakers streaming: FuboTV (Try for free)

Why the Lakers can cover

The Lakers fell on Tuesday by a 127-100 score to the Phoenix Suns, despite Anthony Davis dropping a double-double with 25 points and 15 rebounds. LeBron James nearly had his 118th career triple-double as he had 18 points, 10 assists and eight rebounds, while D'Angelo Russell had 16 points off the bench.

Davis is having an MVP-caliber season, with career-highs in points (29.8) and 3-point percentage (38.2). He also ranks fourth in blocks (2.1), seventh in rebounds (11.4) and has powered the league's No. 5 offense in terms of efficiency. No team makes or attempts more free throws per game than Los Angeles, and that could be a source for easy points versus a Spurs team that struggles to put points on the board, ranking in the bottom 10 in scoring. See which team to pick here.

Why the Spurs can cover

Meanwhile, the Spurs entered their tilt with the Utah Jazz on Tuesday with three consecutive wins but they'll enter their next game with four. The Spurs prevailed, 128-115, in which Victor Wembanyama had 34 points plus seven rebounds and three blocks. The game was his fifth in a row with at least 30 points.

The Spurs have clearly found their groove as two of their wins in their streak came against the top two teams in the West in OKC and Golden State. Wembanyama has built off his historic rookie season and is averaging 23.6 points, 10 rebounds, 3.6 blocks and 3.2 assists. This year's top rookie, Stephon Castle, is putting up 16.3 points over his last nine games. San Antonio also has a couple of spread advantages, covering in each of its last four, while the Lakers are just 2-6 ATS on the road this season. See which team to pick here.

How to make Spurs vs. Lakers picks

The model has simulated Lakers vs. Spurs 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that hits in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Spurs vs. Lakers on Wednesday, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the Lakers vs. Spurs spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.