SANTA CLARA, Calif. (AP) With most of Arizona's biggest stars sitting out with injuries, the Cardinals still had more than enough firepower to overwhelm the San Francisco 49ers.

James Conner ran for two touchdowns and caught a 45-yard TD pass from backup quarterback Colt McCoy as the short-handed Cardinals beat the 49ers 31-17 on Sunday.

The Cardinals (8-1) were playing without quarterback Kyler Murray and receivers DeAndre Hopkins and A.J. Green. They also lost running back Chase Edmonds in the first quarter, but they still had little trouble completing the season sweep against the 49ers (3-5).

''They stepped up,'' coach Kliff Kingsbury said. ''We knew they had to. When you lose some your best players, it's not easy. But that's how this league is. Guys stepped up and made big plays all day.''

Conner finished with 173 yards from scrimmage, McCoy played an efficient game and the defense delivered three takeaways and five sacks, including three from Markus Golden.

Conner scored on TD runs on back-to-back drives in the first quarter to stake the Cardinals to a big lead they never relinquished. Conner's long catch-and-run TD on Arizona's first drive of the second half helped put the game out of reach. Conner leads the NFL with 11 TDs, all scored in the past seven games.

San Francisco lost a pair of fumbles in the first half and struggled defensively even against McCoy, a career backup who had won two starts in the past 10 seasons. McCoy went 22 for 26 for 249 yards.

''We hit on some big plays that really changed the game,'' McCoy said. ''Kliff got me in a rhythm early. James ran the ball hard. I just didn't want to come in here and turn the ball over. We didn't and you win games that way. I'm benefiting from being on a great team and I'm really glad to get out there on the field and guys can help me pull through.''

The Niners are now winless in four home games this season and are just 1-8 at Levi's Stadium the past two seasons. San Francisco trails Arizona by four games in the NFC West and can afford few more slipups if the 49ers hope to make a wild-card push.

''We didn't play very well today at all,'' coach Kyle Shanahan said. ''I was real disappointed. I thought we'd played really well. We had a good week of practice that we'd even improved from the week prior, but obviously it didn't go that way.''

Jimmy Garoppolo played well, throwing for 326 yards and two touchdowns, but the Niners never got the running game established and were gashed on defense. Garoppolo threw a late interception to end any chance at a comeback.

TURNAROUND

A week after committing no turnovers, not punting and not allowing a sack in a win at Chicago, the Niners wasted little time doing all three against Arizona. Golden had a third-down sack on the first drive, leading to a punt.

George Kittle then fumbled after a catch on the first play of the second drive. San Francisco punted again on the third drive and Brandon Aiyuk lost a fumble on the fourth drive.

FOOLED 'EM

The Cardinals set up their second TD with a trick play. Receiver Christian Kirk got the ball on an end-around and launched a deep pass that Antoine Wesley caught for a 33-yard gain to the 1. It was Kirk's first completion in college or the pros. Conner ran it it on the next play to make it 14-0.

Kingsbury said it was a play he used once as a college assistant at Houston and the Cardinals had practiced it all year with Hopkins throwing to A.J. Green. But it finally got called Sunday with a different combo.

''I told (Hopkins) since he's not playing, C-Kirk gets to run it,'' Kingsbury said. ''He made a great throw and Antoine made a great play.''

FLAG DAY

A play with unsportsmanlike conduct penalties on both teams ended up benefiting the Cardinals.

Kingsbury came running on the field to argue a call after the Cardinals failed to convert on a third-and-long in San Francisco territory. The penalty could have knocked Arizona out of field-goal range, except Niners cornerback Josh Norman was called for taunting when he started yelling at Kingsbury while the officials were discussing the first penalty.

The officials enforced the Norman penalty first and then the penalty on Kingsbury. That set the Cardinals up with a first-and-25 from the 26. Arizona settled for a field goal to take a 17-0 lead.

INJURIES

Cardinals: Edmonds (ankle) and LG Justin Pugh (calf) got hurt early and didn't return.

49ers: RT Mike McGlinchey (knee) left with a knee injury.

UP NEXT

Cardinals: Host Carolina next Sunday.

49ers: Host the Los Angeles Rams on Monday, Nov. 15.

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