The NFL Week 15 schedule features a cross-conference matchup between teams in the thick of their respective playoff races with the Los Angeles Chargers (8-5) set to host the Tampa Bay Buccaneers (7-6) on Sunday. Tampa Bay is looking to win its fourth straight game after beating the Las Vegas Raiders 28-13 in their last outing. The Chargers aim to bounce back from a hard fought 19-17 loss to the Kansas City Chiefs that ended on a walk-off field goal by the Chiefs. The Bucs are 8-5, while the Chargers are 9-3-1 against the spread this season.

Kickoff at SoFi Stadium in Inglewood, Calif. is set for 4:25 p.m. ET. The Chargers are favored by 3 points in the latest Buccaneers vs. Chargers odds, while the over/under is 45.5 points per SportsLine consensus. Los Angeles is a -151 money line favorite (risk $151 to win $100), while Tampa Bay is a +127 underdog. Before entering any Bucs vs. Chargers picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2024 NFL season on an incredible 25-11 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 205-139 roll on top-rated NFL picks that dates back to the 2017 season and a 59-32 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns.

The model has set its sights on Buccaneers vs. Chargers and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model's picks. Here are several NFL betting lines for the game:

  • Chargers vs. Buccaneers spread: Chargers -3
  • Chargers vs. Buccaneers over/under: 45.5 points
  • Chargers vs. Buccaneers money line: Chargers: -151, Buccaneers +127
  • Chargers vs. Buccaneers picks: See picks at SportsLine
  • Chargers vs. Buccaneers streaming: FuboTV (Try for free)

Why the Chargers can cover

Veteran quarterback Justin Herbert has thrived under first-year head coach Jim Harbaugh. The former Oregon standout has completed 63.9% of his passes for 2,764 yards, 14 touchdowns, and one interception. Herbert enters this matchup leading the NFL in interception rate. 

The Chargers enter this matchup with the top-ranked defense in the league, allowing an average of 15.9 points per game. Los Angeles has one of the premier defensive fronts in the NFL, led by Tuli Tuipulotu (7.5 sacks), Bud Dupree (5), Khalil Mack (5), and Joey Bosa (4.5). The Chargers are 9-3-1 against the spread this season. See which team to pick here.

Why the Buccaneers can cover

The Buccaneers enter this game on a high note, winning three straight games. Tampa Bay has performed well against the spread this season, going 8-5 against the number thus far. The Bucs are coming off a 28-13 blowout win over the Raiders that was sparked by a dominant defensive performance.

Quarterback Baker Mayfield is having one of the best seasons of his career in 2024. The 2017 Heisman Trophy winner has thrown for 3,329 yards, 28 touchdowns, and 13 interceptions. His top target has been veteran wide receiver Mike Evans, who has 43 catches for 590 yards and seven touchdowns. See which team to pick here. 

How to make Buccaneers vs. Chargers picks

The model has simulated Buccaneers vs. Chargers 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that has all the value. You can only see the pick at SportsLine.

So who wins Pittsburgh vs. Philadelphia on Sunday, and which side of the spread holds all the value? Visit SportsLine right now to see which side of the Chargers vs. Buccaneers spread you should be all over Sunday, all from the model on a 205-139 roll on its top-rated NFL picks, and find out.