Where: Arrowhead Stadium, Kansas City, Mo. (natural grass, outdoors)
When: Sunday, 4:05 p.m. ET (CBS)
Spread: Chiefs by 1.5
Forecast: Cool, partly cloudy.
Records: Chiefs (Overall: 1-5, AFC West: 0-1); Raiders (Overall: 2-4, AFC West: 0-2)
Past results: Two most recent meetings -- Dec. 24, 2011: Raiders 16, Chiefs 13; Oct. 23, 2011: Chiefs 28, Raiders 0. Series record: Chiefs lead 53-48-2.
What matters: For the first time all year, the Chiefs are finally healthy. It's tough to blame how bad they have been on injuries, but injuries have at least contributed to the mess in Kansas City. RB Peyton Hillis returning to the lineup should help lighten the load on Jamaal Charles, who has 96 touches in the last four games. The Chiefs have gone to an uber-conservative offensive approach in the last two games, but the numbers say it's probably better to try to attack Oakland through the air. The Raiders rank 12th against the run (102.1 yards per game) and 22nd against the pass (254.7 yards per game).
Who matters: The quarterbacks. The Chiefs are going with Brady Quinn over Matt Cassel, which is probably more catering to their fans than anything else. They have tried to do everything they can to take the pressure off the quarterback by running at every opportunity. Now that Quinn has had three weeks of practice as the starter, conventional wisdom says the Chiefs will open it up a little bit against the Raiders. It also wouldn't be shocking to see them stick to their conservative ways. In Kansas City's last loss, Josh Freeman lit up the Chiefs for 328 yards on 15 completions. The Bucs were able to attack Kansas City's secondary down field. That's what Carson Palmer and the Raiders do best. If Palmer has a similar game to Freeman, it will be tough for the Chiefs to keep up.
Key matchups: Oakland WRs vs. CB Stanford Routt. Routt was beaten on two 62-yard passes from Freeman against the Bucs. Both passes were jump balls that Routt lost. The former Raider has not had a good season to date. With Brandon Flowers playing well on the other side, expect the Raiders to go after their former teammate. WR Dwayne Bowe vs. Oakland corners. Bowe had nine targets against Tampa Bay, but he caught only three passes for 21 yards. To this point in the season, Jonathan Baldwin has been a disappointment (13 catches and no touchdowns) and Steve Breaston rarely plays. The Chiefs need Bowe to be productive.
Injuries of note: Hillis (ankle) is listed as probable. DE Glenn Dorsey (calf), TE Steven Maneri (ankle) and CB Jalil Brown (groin) are all questionable.
Inside stuff: DE Tamba Hali called the Raiders dirty this week. That has always been the perceptions of the Raiders, so it's not like Hali sent shockwaves through the NFL with his statement. It's worth keeping an eye on what goes on after the whistle between Hali and Oakland's offensive line.
Connections: Routt played for Oakland for seven seasons before signing with the Chiefs as a free agent. Oakland's senior offensive assistant Al Saunders was the offensive coordinator on some of the most successful Kansas City offenses from 2001-2005.
Stat you should know: The Chiefs have yet to play with a lead all season -- they beat New Orleans on the last play of overtime. The last time a team went six games without playing with a lead was Houston in 2005. The Texans got their first lead and won for the first time in their seventh game against Cleveland, coached by Romeo Crennel.
Looking ahead: The Chiefs travel to San Diego for a Thursday night game. The bye week was much needed to get the Chiefs healthy and clear their minds of a bad start. However, if they lose at home to Oakland, they could be a deflated team on Thursday.
Prediction: Oakland 17, Kansas City 13
Follow Chiefs reporter C.J. Moore on Twitter @CBSChiefs and @cjmoore4.