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Long time NFC East rivals, the New York Giants and Washington Commanders, meet in Week 2 of the 2024 NFL season. Both teams lost in Week 1: New York fell 28-6 at home to Minnesota, while Washington lost 37-20 to Tampa Bay. The Giants are 3-0-1 in their last four games versus the Commanders, including 14-7 and 31-19 victories in 2023.

Kickoff from Northwest Stadium in Landover, Md., is set for 1 p.m. ET. Washington is a 1.5-point favorite in the latest Commanders vs. Giants odds, per SportsLine consensus, while the over/under for total points is 43.5. Before making any Giants vs. Commanders picks, you need to see the NFL predictions and betting advice from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2024 NFL season on an incredible 184-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 38-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on New York vs. Washington and just locked in its picks and NFL Week 2 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for spread, money line and over/under:

  • Giants vs. Commanders spread: Commanders -1.5
  • Giants vs. Commanders over/under: 43.5 points
  • Giants vs. Commanders money line: Commanders -124, Giants +104
  • Giants vs. Commanders picks: See picks at SportsLine

Why the Giants can cover

Rookie wide receiver Malik Nabers looks to be a future NFL star, having caught five passes for 66 yards in his NFL debut. With better quarterback play, he is likely to be a major problem for defenses going forward. The sixth overall pick in April's NFL Draft may have the talent, but he wasn't helped by his quarterback play in Week 1 vs. Minnesota.

Quarterback Daniel Jones struggled once again, completing 22 of 42 passes for 186 yards, with no touchdowns and two interceptions. Since the beginning of 2023, Jones has played in seven games, throwing for seven interceptions with only two touchdown passes. Against a Washington secondary that surrendered 289 yards passing and four touchdowns to Baker Mayfield last week, Jones might have an opportunity to turn around his fortunes, ideally involving Nabers early and often. See which team to pick here.

Why the Commanders can cover

Washington quarterback Jayden Daniels showed glimpses of why he was drafted as the No. 2 overall pick in April's draft by the Commanders. Against Tampa Bay in Week 1, he completed 17 of 24 passes for 184 yards, while rushing 16 times for 88 yards and two scores. The reigning Heisman Trophy winner from LSU is dynamic with his arm and his legs and should pose significant issues for defenses in the years to come.

Veteran running back Austin Ekeler made his Commanders debut alongside incumbent running back Brian Robinson Jr., with both not being overly successful on the ground. They combined for 50 yards rushing on 14 attempts, but managed seven receptions from Daniels for 101 yards in the team's defeat last Sunday. For Washington to win on Sunday, it will need a more successful thunder and lightning running back performance from Robinson and Ekeler, in addition to Daniels' performance. See which team to pick here.

How to make Giants vs. Commanders picks

The model has simulated Giants vs. Commanders 10,000 times and the results are in. It is leaning Under on the point total, and it also says one side of the spread hits well over 50% of the time. You can only see the model's Giants vs. Commanders pick at SportsLine.

So who wins Washington vs. New York on Sunday, and which side of the spread hits well over 50% of the time? Visit SportsLine right now to see which side of the Commanders vs. Giants spread you should be all over Sunday, all from the model on a 184-130 roll on its top-rated NFL picks, and find out.