The Los Angeles Rams earned the right to host a Wild Card Weekend matchup in the 2025 NFL playoffs, but due to the devastating wildfires in the Los Angeles area, Vikings vs. Rams (+2.5, 47.5) has been moved to State Farm Stadium in Glendale, Ariz. The teams will still kick off at 8 p.m. ET on Monday. Rams wide receiver Puka Nacua finished as the WR2 in Fantasy football on a points-per-game basis this season and had 10 receptions for 129 yards at home against the Cardinals in Week 17 before the Rams rested their starters in Week 18, so even with a high price tag for NFL DFS picks, is Nacua a must-roster for NFL DFS lineups?
Wide receiver is the strongest skill position in the Rams vs. Vikings NFL DFS player pool with Justin Jefferson, Jordan Addison and Cooper Kupp also available, so which players should you include in your NFL DFS strategy? Before locking in any NFL DFS picks for Monday Night Football of Wild Card Weekend for Vikings vs. Rams on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor.
Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who cashed big all season in 2022, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks on sites like DraftKings and FanDuel.
Kaylor has hit on epic NFL DFS picks for SportsLine members. He was all over slate-breaking performances like Travis Kelce's (7-25-4), Kirk Cousins (460-4), T.J. Hockenson's (13-109-2), Ja'Marr Chase's (15-1923), D.J. Moore's (8-230-3), and De'Von Anchane (233 total yards, four TDs). This season, some of Kaylor's top picks include Green Bay wide receiver Jayden Reed (4-138-1, 33-1) and James Cook (78-2). Anyone who followed his picks on sites like DraftKings and FanDuel could be way up.
Now, Kaylor has turned his attention to Wild Card Weekend on Monday Night Football for Rams vs. Vikings in the 2025 NFL playoffs and locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.
Top NFL DFS picks for Vikings vs. Rams on Monday
One of Kaylor's top NFL DFS picks for Wild Card Weekend on Monday Night Football is Vikings wide receiver Justin Jefferson. The 25-year-old is the highest-paid wide receiver in the NFL and despite proving to be worthy of that contract, plenty of season-long Fantasy football players questioned how productive he'd be with Sam Darnold as his quarterback. Instead of Darnold hurting Jefferson's value, the two elevated one another as Jefferson posted 103 receptions for 1,533 yards and 10 touchdowns to finish as the WR2 in Fantasy football this season. Jefferson has had at least 1,000 yards in all five of his NFL seasons and he holds the NFL record for receiving yards per game (96.5).
Jefferson averaged 108 yards over his prior five games entering the final week of the regular season as the Vikings struggled to do much of anything offensively in a 31-9 loss to the Lions. He was held to three receptions and 54 yards, but Jefferson was targeted nine times as Minnesota tried to find ways to scheme him open. The elite receiver is averaging 11.8 targets over his last four games and is sure to be heavily involved on Monday. See who else to roster here.
Kaylor's Monday Night Football Wild Card Weekend NFL DFS strategy also includes rostering Rams running back Kyren Williams. He rushed for 56 yards and a touchdown while adding three receptions for 16 yards in Week 17 against the Cardinals. The 24-year-old has at least one touchdown in five of his last six games and he was seventh in the NFL in rushing at 1,299 yards this season.
He's taken on a bell cow role all season, but that could increase even more with the importance of every snap during the playoffs and backup running back Blake Corum placed on IR with a forearm injury. Williams played at least 83% of snaps in each of his last four games, even with Corum active, and he's played at least 89% of snaps in eight of his 16 games this season. His usage and production make Williams a top option for Monday Night Football NFL DFS lineups. See who else to roster here.
How to set Monday NFL DFS lineups, player pools
Kaylor is also targeting another undervalued player who could explode for huge numbers for Wild Card Weekend Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of Kaylor's NFL DFS picks, at SportsLine.
So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Rams vs. Vikings on Monday Night Football, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from an NFL DFS expert who won a prestigious Millionaire Maker tournament, and find out.
