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The San Francisco 49ers host the Chicago Bears in the Week 17 edition of 'Sunday Night Football' at 8:20 p.m. ET. Both teams are battling for playoff positioning, so they won't be holding anything back as the regular season begins to wind down. Top options in the NFL DFS player pool include Christian McCaffrey, Caleb Williams, D'Andre Swift and Brock Purdy. Both teams have some injury concerns at the skill positions with Chicago receiver Rome Odunze (foot) ruled out and the Niners listing tight end George Kittle (ankle) and Ricky Pearsall (knee, ankle) as questionable.

How should you build your NFL DFS lineups for 'Sunday Night Football,' and which sleepers should factor into your NFL DFS strategy? Before making any Bears vs. 49ers DFS picks, be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure.

You can also bet props like D'Andre Swift as anytime TD scorer (+140) using the latest DraftKings promo code, which offers $200 in bonus bets if your bet wins:

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him could be way up.

Now, McClure has turned his attention to the 'Sunday Night Football' DFS slate and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine. 

Top NFL DFS picks for Bears vs. 49ers

One of McClure's top NFL DFS picks is San Francisco running back Christian McCaffrey. One of the premier daily Fantasy options in the league, McCaffrey enters this matchup on a five-game touchdown streak. He also had 146 scrimmage yards last week against the Colts. He produced 117 of those on the ground, but his two touchdowns came via short passes, illustrating how tough it is to contain him for opposing defenses. See who else to roster at SportsLine.

You can also bet on McCaffrey to go Over 117.5 rushing + receiving yards (-113) at DraftKings:

He's also building around Bears tight end Colston Loveland. He's still being used in plenty of two tight-end sets with Cole Kmet, but Loveland, the rookie out of Michigan, has become the clear TE1 in this offense. Ben Johnson's offense produced huge numbers for Sam LaPorta as a rookie and second-year player in 2023 and 2024, and Loveland is pacing in the same direction. The Niners are tough overall on defense, but have given up the 22nd most Fantasy points to opposing tight ends. See more NFL DFS picks at SportsLine.

Bet Loveland to go Over 40.5 receiving yards (-112) at DraftKings:

How to set 49ers vs. Bears NFL DFS lineups

McClure is targeting another undervalued player who could explode for huge numbers on 'Sunday Night Football'. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure's NFL DFS picks, at SportsLine.

So who is Mike McClure including in his optimal NFL DFS lineups for 'Sunday Night Football', and which under-the-radar player offers huge value? Visit SportsLine now to see optimal NFL DFS picks, NFL DFS rankings, NFL DFS advice and NFL DFS stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.