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The 2026 NFL playoffs begin their second stage with the divisional round taking place this weekend. Saturday's matchups you can make NFL picks on are Bills vs. Broncos (+1) and Seahawks vs. 49ers (+7), while Sunday's contests are Patriots vs. Texans (+3) and Rams vs. Bears (+3.5). New England has won eight straight divisional round games, while San Fran has won seven in a row, which are the two longest streaks in NFL history. So, should the Pats and Niners heavily factor into your NFL bets, player props or as part of a winning NFL parlay?

Meanwhile, Denver is just a 1.5-point favorite despite having a bye and being the top seed. With the Bills dominating the Broncos to the tune of a 31-7 victory in last year's Wild Card round, Denver has several things to motivate it for Sunday's contest. How should that impact your divisional round NFL predictions? Before locking in any divisional round NFL picks or NFL prop bets, be sure to check out the divisional round NFL best bets and predictions from SportsLine's red-hot Vegas experts. 

SportsLine has more than 40 hand-picked Vegas experts who excel in multiple spots. The NFL, however, is a strength for the site as SportsLine currently has five total experts who are on NFL runs that have returned $1,000 or more for $100 players and one who has returned more than $1,500. Anybody following their NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, with the divisional round NFL schedule quickly approaching, SportsLine's top NFL experts are already locking in their picks. Go to SportsLine to see them all now.

Top divisional round NFL expert picks from Doug Kralstein

Better known as 'Prop Bet Guy,' Kralstein specializes in player props, and since joining SportsLine in 2024, he is up 112 units on his NFL player props. He enters the divisional round on another strong run, going 61-40 (+1475) on his past 101 NFL player props. 

This week, he is backing Bills receiver Khalil Shakir Over 4.5 receptions (-130) versus Denver on Saturday. "Running most his routes out of the slot, he'll avoid Patrick Surtain on the outside. The Broncos allow the fifth-highest target rate to slot pass catchers (36%, per Fantasy Points). Denver allowed the third most catches to pass catchers in the slot and out wide for nine air yards or less (11.2 per game). Shakir's aDOT is 3.6 yards, with 82% of his targets coming in at less than 10 air yards." See all of Kralstein's picks here, and new users can target the DraftKings promo code, which offers $300 in bonus bets if your bet wins:

Top divisional round expert NFL picks from Micah Roberts 

Roberts, a 20-year veteran of the Vegas sportsbook industry, is on a 19-4 run (+1460) with picks in San Francisco games and is also on a 7-3 roll (+374) with over/under predictions. 

This weekend, he is backing the Over (44.5) in 49ers vs. Seahawks on Saturday. "It's the 49ers' offense that helped them get over the total in 10 games this season. The 49ers' defense has been nothing to brag about... and they go back to work Saturday night. They're going to give up a few scores and score a few more on their own. Over." See the rest of Roberts' picks here, and bet the Under here:

How to make divisional round NFL picks

SportsLine's team of experts also includes R.J. White, SportsLine's No. 1 NFL expert who has returned more than $3,200 to $100 players since 2017. He's already locked in four best bets for the NFL divisional round, including a spread pick in a game where he says the line is off. You can find out who his NFL picks are this weekend here. 

If you are looking for NFL picks, NFL props, or NFL best bets for the divisional round, SportsLine has you covered with its proven team of experts. Visit SportsLine now to see who which teams you should back in the divisional round, all from a staff that includes five experts who are on NFL runs that have returned $1,000 or more for $100 players.