NFL Week 16 odds, predictions, expert picks: Can Patriots bounce back? Can Lions keep playoff hopes alive?
CBS Sports and SportsLine break down Week 16's late slate of games, plus SNF and MNF
With just three weeks left in the 2025 regular season, these games carry substantial weight as we continue to mold the playoff picture. In Week 16, there are several playoff-clinching scenarios in which teams could punch their tickets to the postseason, including the San Francisco 49ers and New England Patriots facing win-and-in situations. Those raised stakes make the upcoming slate that much more entertaining to not only watch, but wager on as well.
As we do every week throughout the season, we've collected all of the best picks and gambling content from CBS Sports and SportsLine and put them in one convenient place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. Ready? Let's jump in.
All NFL odds via DraftKings Sportsbook.
Falcons at Cardinals
Sunday, 4:05 p.m. on Fox (Stream: Fubo -- try for free)
Falcons -2.5: "These two are among the biggest disappointments of the year. The Cardinals are decimated by injuries, which shows up on defense. The Falcons showed they could score against Tampa Bay with Kirk Cousins at quarterback and that will continue in this one. Falcons win it." -- CBS Sports Senior NFL analyst Pete Prisco on why he has Atlanta covering in Arizona. To see the rest of his Week 16 picks, click here.
Jaguars at Broncos
Sunday, 4:05 p.m. on Fox (Stream: Fubo -- try for free)
Broncos -3: "If I'm worried about anything here, it's whether the Jags defense can slow down the Broncos offense. Bo Nix has gotten hot over the past few weeks: He's averaging 282.5 passing yards per game over the past four weeks and the Jaguars are 2-3 this season when their opponent throws for more than 280 yards. The Broncos are a perfect 7-0 at home this year and they have a lot to play for: If they go 2-1 in their final three games, they'll clinch the No.1 overall seed in the AFC no matter what happens in any other game. I feel like the Jags will keep this close, but the Broncos end up winning a thriller, which means no one will get to see Jaxson De Ville in a thong, except maybe Mrs. De Ville." -- CBS Sports NFL writer John Breech on why he has Denver staying perfect at home with a win over Jacksonville. To see the rest of his Week 16 picks, click here.
Raiders at Texans
Sunday, 4:25 p.m. on CBS (Stream on Paramount+)
Texans -14.5: "The Raiders are bad right now with little semblance of an offense, while the Texans are the best defense in the league. That's a bad combination. The Raiders are also playing consecutive road games with no chance for the playoffs, while the Texans would be in the postseason right now and need it. Texans in a blowout." -- CBS Sports Senior NFL analyst Pete Prisco on why he has Houston covering the monster spread, 31-9. To see the rest of his Week 16 picks, click here.
Steelers at Lions
Sunday, 4:25 p.m. on CBS (Stream on Paramount+)
Lions -7: "I just don't think the Steelers can score enough to keep up with the Lions -- even against an injury-ravaged Detroit defense. You can run on the Steelers, as we have seen in recent weeks, and this feels like a game where Jahmyr Gibbs gets back on track in a big way after he struggled to run the ball against the Rams last week. Unless an offensive explosion comes out of nowhere for Pittsburgh, I like the Lions to win big." -- CBS Sports' Jared Dubin on why he has the Lions taking down Pittsburgh, 31-17. To see the rest of his picks, click here.
Ravens at Patriots
Sunday, 8:20 p.m. on NBC (Stream: Fubo -- try for free)
SportsLine's Mike Tierney is the expert you want in your corner when trying to zero in on a wager for Sunday night's matchup between the Patriots and Ravens. In his last 46 picks involving Baltimore, Tierney is on a 31-14 roll (+2505), making him a must-see source in Week 16. We can tell you he's leaning Under the 48.5 total, but to see his official play for Sunday's primetime affair, you'll need to go to SportsLine.
Ravens -3: "If the Ravens offense has struggled at one thing this year, it's scoring in the red zone. They've scored a touchdown on just 44% of their trips, which ranks 31st in the NFL. The good news for the Ravens is that the Patriots are the perfect opponent to face when you're trying to fix your red zone issues. The Patriots' defense has surrendered a TD on 75% of opponents' red-zone trips, which ranks dead last in the NFL (to put that in perspective, only three teams are above 70%, including New England). The Ravens are healthy and they're going to be desperate because a loss could crush their playoff hopes. I'll say they keep their postseason dreams alive with a big win against New England." -- CBS Sports NFL writer John Breech on why he likes Baltimore to pull off the win against the Patriots on Sunday night. To see all of his Week 16 picks, click here.
49ers at Colts
Monday, 8:15 p.m. on ESPN (Stream: Fubo -- try for free)
Need a little help formulating your pick for this "Monday Night Football" showdown in Indy? Allow SportsLine's Micah Roberts to be of assistance. He's been the go-to source when it comes to betting on games involving the 49ers, owning an 18-4 record over his last 22 picks. Now, Roberts has released his best bet for the Week 16 finale, so you won't want to miss how he's attacking this matchup. We can tell you he is leaning Under the 46.5 point total, but to see his official spread pick, you'll need to go to SportsLine.
49ers -6.5: " Grandpa Rivers did a pretty solid job in his return to the field last week against Seattle. It's almost embarrassing that the Seahawks needed a game-winning field goal to win. I imagine Lucas Oil Stadium is going to be rocking for this prime-time matchup, but the difference in this game is going to be the 49ers' offense vs. the Colts' defense. The versatile Christian McCaffrey has been one of the best players in the entire NFL this season, George Kittle has crossed 65 yards receiving in five straight games, Jauan Jennings caught two touchdowns last week and Brock Purdy has found a rhythm. With the number under a touchdown, I have to roll with the 49ers." -- CBS Sports' Jordan Dajani on why he has the Niners covering in Indianapolis as one of his top bets of Week 16. To see the rest of his picks, click here.
