The Carolina Panthers defense had a strange 2012. Even though they allowed an NFL-worst 66.85 percent completion rate and gave up 223 yards per game, the Panthers still held opposing quarterbacks to the ninth-fewest Fantasy points per game. And they allowed just 9.19 rushing yards per game to quarterbacks, the fifth-lowest rate in the NFL.
While Seahawks quarterback Russell Wilson can run, he's not reliant on it. In last year's matchup, the Panthers held Wilson to 221 yards passing and a touchdown, with two interceptions and just 12 rushing yards. Additionally, the Panthers led the NFL with 10 interceptions in the preseason; we tend to take preseason stats with a grain of salt, but Carolina's defense looked exceptional in the four games, and could be underrated heading in.
Wilson is a very talented quarterback, but should probably be left on the bench in 12-team leagues (wherever possible). He doesn't have a reliable group of receivers and he's going up against a defense that is quietly suited to stop his brand of play.