The Rams have struggled as road underdogs over the past two years, covering the spread at just a 4-10-1 clip in their last 15 games in that role. They are 3-point road underdogs against Chicago on Sunday in the Week 4 NFL odds. The Bears are coming off back-to-back road losses, but rookie quarterback Caleb Williams threw for 363 yards and two touchdowns against the Colts last week. Can you trust him to cover the spread against Los Angeles when you build your Week 4 NFL parlay picks?

Broncos rookie quarterback Bo Nix will also be in action on Sunday, as Denver is a 7.5-point road underdog against the Jets in the Week 4 NFL spreads. Nix led the Broncos to a 26-7 upset win at Tampa Bay last week, while the Jets are coming off consecutive wins over Tennessee and New England. Before you make any Week 4 NFL picks or NFL parlays, be sure to see what SportsLine senior analyst Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. His weekly Vegas contest selections form the basis of his NFL best bets column, which is 83-52-3 (61.5%, +25.50 units) since its inception in 2022. He went 2-1 last week.

For Week 4, Hartstein has locked in three confident best bets. If you successfully parlay his picks, you're looking at a payout of over 6-1. You can only see Hartstein's Week 4 NFL picks at SportsLine.

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Top Week 4 NFL picks

We can tell you Hartstein loves the Steelers (-2, 40) on the road versus the Colts. Indianapolis was able to pick up its first win of the season last week against Chicago, as running back Jonathan Taylor rushed for 110 yards and two touchdowns. It will be difficult for him to have the same level of success this week against a Pittsburgh defense that has allowed 26 total points across its first three games.

The Steelers lead the NFL in total yards allowed per game (229.0) and rank third in rushing yards allowed per game (71.3). They will put pressure on Colts quarterback Anthony Richardson, who has completed less than 50% of his passes with three touchdowns and six interceptions. Hartstein expects Richardson to turn the ball over several times on Sunday against a stingy Pittsburgh defense, which is one major reason why he is picking the Steelers to record their fourth win. See which other NFL parlay picks to make here.

How to make Week 4 NFL parlays

Hartstein also jumped on two other NFL matchups, including backing one team whose quarterback "typically thrives in this matchup." You can only see Hartstein's Week 4 NFL best bets and parlay at SportsLine

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What are Hartstein's top Week 4 NFL picks, and which other NFL matchups should you target for a strong 6-1 payout? Visit SportsLine now to see the Week 4 NFL best bets from the Vegas expert who is up 25.50 units on NFL ATS picks, and find out.