Ravens LT Michael Oher vs. Cowboys OLB DeMarcus Ware: Oher is the Ravens' best tackle, but he faces a tough test here against the speedy and strong Ware. If Ware gets going, it could be a long night for Oher and the Ravens offense. We will see how Oher holds up on the blind side.
Seahawks S Earl Thomas and Kam Chancellor vs. Patriots TE Rob Gronkowski: Thomas and Chancellor are considered one of the best safety duos in the league. Thomas is the best cover guy, but Chancellor is the better hitter and the bigger player. I would imagine both will spend some time on Gronkowski. Whenever they are on him, it will be a tough challenge.
Rams DE Robert Quinn vs. Dolphins LT Jake Long: Quinn is emerging as one of the best young outside rushers in the league. He had a field day against the Cardinals last week, but this is a big step up in terms of talent with Long. Quinn will have a real big chance to show how he is truly blossoming with a big game against Long.
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Packers OLB Clay Matthews vs. Texans LT Duane Brown: Matthews leads the NFL in sacks and is a relentless pass rusher. He also plays the run well. Brown is arguably the best left tackle in the game, a player who doesn't get the due he deserves. This could be his chance to show the nation how good he is as a player.
49ers OL vs. Giants DL: I usually don't go unit vs. unit, but this battle is too good to pass up. The 49ers might have the best overall line right now. The Giants have a great defensive line loaded with pass rushers. The key might be how well the Giants' inside people play against the 49ers' guards.
Falcons WRs Julio Jones and Roddy White vs. Raiders CBs Patrick Lee and Michael Huff: The Falcons have an explosive outside combination, while the Raiders have a former safety (Huff) and a former Green Bay backup (Lee) as their starting corners. Matt Ryan could have a big day.
Cowboys LT Tyron Smith vs. Ravens DE Haloti Ngata: Smith is in his second season, first on the left side of the line. He will face a tough task in the powerful Ngata, who is coming off a so-so game last week against the Chiefs.
Lions WR Calvin Johnson vs. Eagles CBs Nnamdi Asomugha and Dominique Rodgers-Cromartie: Johnson will probably see a lot of both of these corners. Asomugha has been struggling lately, so look for him to get some help when he is on Johnson. Rodgers-Cromartie is a gambler type who can give up the big play, but can get one too.
Vikings WR/RB Percy Harvin vs. Redskins CBs DeAngelo Hall and Josh Wilson: Wilson has struggled this season, so I would expect to see Hall on him a lot. Harvin is off to a fast start and keys the Vikings offense now. He did back off some in practice becasue of a tight hamstring, so keep an eye on that. Look for the Redskins to do whatever they can to take him away.
Chargers RT Jeromey Clary vs. Broncos OLB Von Miller: Clary has struggled at times with speed rushers. Miller is one of the best edge rushers from the linebacker spot. He is coming off an impressive game against the Patriots, so he has it rolling.