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Fresh off an 11-win season, the Missouri Tigers have their sights set on making the expanded College Football Playoff and they're ranked sixth in the AP Top 25 after shutout wins over Murray State and Buffalo to open the season. However, they'll face their toughest test yet on Saturday when they host Boston College for one of two ranked matchups on the Week 3 college football schedule. New head coach Bill O'Brien earned an upset win over Florida State to open the season and is ranked 24th now after a 56-0 win over Duquesne last week.

Missouri is a 14.5-point favorite in the Week 3 college football odds via the SportsLine Consensus, but BC already has a win this season as a big underdog, beating FSU at +16.5. So who should you be backing in that game, and what other Week 3 college football lines should you be targeting as you put together your Week 3 college football parlays. Before locking in any Week 3 college football picks, be sure to see the top Week 3 college football expert picks, predictions and best bets from Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. Over the past two college football seasons, Casale is 122-92-5 (57%) overall on his college football picks and 26-8 (76.4%) in bowl games -- all publicly documented. Anybody who has followed him is way up.

Now, he has turned his attention to the Week 3 college football odds and is sharing his top three best bets over at SportsLine. If you parlay them together, you could be looking at a return of around 6-1. Get his top college football picks at SportsLine.

Top Week 3 college football expert predictions

One of Casale's top Week 3 college football picks: No. 4 Alabama (-16.5) against Wisconsin on Saturday. Both teams are 2-0, with Wisconsin beating Western Michigan and South Dakota by 14 points each, while Alabama blew out Western Kentucky 63-0 and beat South Florida 42-16 thanks to a late 28-3 run.

Heisman Trophy candidate Jalen Milroe has already accounted for nine touchdowns and the Crimson Tide offense shoulder benefit from the expected return of starting left tackle Kadyn Proctor. Elijah Pritchett also slid back into the lineup at right tackle last week after Wilkin Formby was called for four holding penalties and 80% of Alabama's offense was produced after the switch.

"I'm also not sold on Tyler Van Dyke at quarterback in Wisconsin's Air Raid offense. In two games against inferior competition (Western Michigan, South Dakota), the Badgers are averaging just 27.5 points and 203 passing yards per game," Casale told SportsLine. See what other picks Casale likes at SportsLine

How to make Week 3 college football picks 

Casale has also found two other college football picks he loves, including backing an underdog against the spread in a massive rivalry game. You can only see his picks at SportsLine.

What are the best bets for Week 3 of college football, and which underdog should you be all over? Visit SportsLine now to see Thomas Casale's college football best bets, all from a proven college football handicapper who has gone 26-8 on bowl games the past two seasons, and find out.