Perdomo is out of the lineup for the second game of Wednesday's doubleheader with the Guardians, Jesse Friedman of GoPHNX.com reports.
Perdomo made a fifth consecutive start in the first game of the day, going 1-for-4 with a two-run home run in the Diamondbacks' 7-3 win. He'll retreat to the bench for the nightcap while Kevin Newman receives a turn at shortstop.
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