McCutchen left Thursday's game in the sixth inning with right thumb discomfort.
After lining out to short in the top of the sixth, McCutchen was replaced in center field by Starling Marte in the bottom of the frame, with Sean Rodriguez taking over in left field. The Pirates have not given any hint as to the severity of the injury, so McCutchen's availability for Friday's series opener against the Angels and the rest of the weekend is uncertain.