The Pirates designated Wendzel for assignment Sunday, Alex Stumpf of MLB.com reports.
He'll give up his spot on the 40-man roster to right-hander Noah Murdock, who exercised an upward-mobility clause in his minor-league contract. Wendzel, 29, appeared in two games for the Pirates back in June but has otherwise spent the entire campaign at Triple-A Indianapolis, with whom he's produced a .230/.349/.461 slash line and 10 home runs across 261 plate appearances.