Mayer is out of the lineup for Wednesday's game against the Brewers, Chris Cotillo of MassLive.com reports.

With southpaw Shane Drohan on the hill for Milwaukee, Mayer and fellow left-handed hitters Jarren Duran and Masataka Yoshida will be held out of the starting nine. Isiah Kiner-Falefa will replace Mayer at second base and will bat ninth.

Mead went 3-for-4 with a home run, two RBI and a stolen base in Tuesday's 7-6 extra-inning loss to the Cardinals.

Getting the start at first base and batting second, Mead took left-hander Matthew Liberatore deep for a solo shot in the fifth inning, giving the Nationals a 5-2 lead that the bullpen would eventually squander. The 25-year-old has mainly been used as a short-side platoon partner for Luis Garcia since arriving in Washington, and he's finding a groove in that role -- over the last four games he's gone 5-for-11 with two doubles, a homer and three RBI. If Mead keeps producing, he could begin to see more work at DH and against right-handed pitching.

Mears allowed no hits and a walk while striking out two over a scoreless inning in Tuesday's 2-1 loss against Cleveland.

Mears delivered a clean eighth inning Tuesday, with a Chase DeLauter walk serving as the only blemish in a scoreless frame that kept the game tied heading into the ninth before a Cleveland walk-off. Coming off a 3.49 ERA and 0.97 WHIP across 56.2 regular-season innings last year with Milwaukee, Mears is off to a strong start this campaign with Kansas City, as he's yet to allow a run through five innings while already picking up a win and a hold.

Cavalli didn't factor into the decision Tuesday, allowing two runs (one earned) on four hits and four walks over 4.2 innings in a 7-6 extra-inning loss to the Cardinals. He struck out three.

The right-hander was able to limit the damage over his 94 pitches (53 strikes), but it was another inefficient performance from Cavalli. He's lasted five innings only once in his first three starts this season, and while Cavalli does sport a 2.51 ERA through 14.1 innings, his 1.47 WHIP and 11:9 K:BB are far less appealing for fantasy GMs. Cavalli will try to secure his first win of 2026 in his next outing, which is set to come on the road early next week in Pittsburgh.

Fermin is not in the lineup for Wednesday's game versus the Pirates.

Fermin started at catcher in the first two games of the series, so he'll get a breather during Wednesday's matinee. Luis Campusano will be behind the dish and bat eighth for the Padres.

Walker went 1-for-5 with a home run and two RBI in Tuesday's 7-6 extra-inning win over the Nationals.

The 23-year-old slugger took PJ Poulin deep for a solo shot in the seventh inning, kicking off a late Cardinals rally from a 5-2 deficit. It's the third homer in the last four games for Walker, a stretch in which he's racked up seven hits and eight RBI as he begins to convert his potential into real production. Through 11 contests to begin the season he's slashing .300/.364/.650 two doubles, four homers, nine runs, 11 RBI and a steal.

Machado is not in the lineup for Wednesday's game in Pittsburgh.

Machado will receive his first day off of the season after slashing .206/.400/.353 with one home run and an 11:11 BB:K over his first 45 plate appearances. The Padres will roll with Miguel Andujar at third base in Wednesday's rubber match.

Pasquantino went 0-for-3 with a walk in Tuesday's loss to the Guardians.

Pasquantino went hitless, reaching base only once via a walk in the eighth inning, though nothing came of it in a low-scoring loss for the Royals. After hitting three homers in six games for Team Italy in the World Baseball Classic, Pasquantino has gotten off to a slow start to the regular season, slashing .195/.306/.220 through 11 games. While the sample is far too small to raise significant long-term concern, Kansas City could opt to give Pasquantino an off day soon to allow him to reset after starting every game to open the year.

O'Brien allowed an unearned run while striking out two in the 10th inning Tuesday to record his third save of the season in a 7-6 win over the Nationals.

The right-hander couldn't stop the phantom runner from coming around to score on a groundout and a wild pitch, but O'Brien fanned CJ Abrams and Nasim Nunez to lock down the victory. He's now picked up the Cardinals' last three saves and is emerging as the top option in the bullpen, with JoJo Romero and Ryne Stanek in setup roles. Through six appearances this season, O'Brien has a 0.00 ERA, 0.63 WHIP and 7:0 K:BB in 6.1 innings, adding a win and two holds to his ledger.

Liberatore didn't factor into the decision in Tuesday's 7-6 extra-inning win over the Nationals, giving up four runs on nine hits and two walks over five innings. He struck out six.

The southpaw was tagged for homers by James Wood in the third inning and Curtis Mead in the fifth and exited the game with the Cardinals in a 4-2 hole, but the offense bailed him out late. Liberatore tossed 59 of 92 pitches for strikes and has lasted at least five innings in all three of his starts to begin the year, posting a 3.38 ERA, 1.50 WHIP and 10:5 K:BB over 16 frames. He'll look for his first win of 2026 in his next trip to the mound, which lines up to come at home early next week against the Guardians.