Joe Mixon was a highly effective back during his time in Cincinnati, logging four 1,000-yard seasons in seven seasons with the Bengals. However, the veteran looks better than ever in a new offense, producing 967 scrimmage yards and 11 touchdowns in his first eight games with the Texans. Mixon has scored a touchdown and logged at least 90 scrimmage yards in every game he's finished this season and become a staple in Fantasy football lineups. Mixon, Saquon Barkley, Derrick Henry and Josh Jacobs have all excelled for new teams this season and continue to play a critical role in their respective offenses. Where do they belong in the Week 12 Fantasy football RB rankings and how can you be sure you're nailing any difficult Fantasy football start-sit decisions? Before setting your Week 12 Fantasy football lineups, be sure to check out the Week 12 Fantasy football rankings from the proven computer model at SportsLine.
When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons, especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.
The same model has a proven track record of providing Fantasy football tips, including being ahead of the curve on players like A.J. Brown, Jonathan Taylor, Derrick Henry, Christian McCaffrey, Alvin Kamara, and Jahmyr Gibbs. Anybody who banked on players like those made a run at their league title.
Now, SportsLine has simulated the entire Week 12 NFL schedule 10,000 times and released its latest Week 12 Fantasy football rankings. Head to SportsLine now to see them.
Top Week 12 Fantasy football QB rankings
Here's a look at SportsLine's top Week 12 Fantasy football QB picks:
1. Jayden Daniels, Washington Commanders: The frontrunner for NFL Offensive Rookie of the Year honors hasn't been at his best in the last couple of weeks while playing through a rib injury but he's had a mini bye to prepare for the Cowboys and head coach Dan Quinn says he's finally healthy enough for a full week of practice. He'll match up with a Dallas defense that ranks 31st in the NFL in points allowed.
2. Jalen Hurts, Philadelphia Eagles: Hurts' streak of four consecutive games accounting for three or more touchdowns ended last week against the Commanders but he did score a rushing touchdown for a fifth consecutive game and is up to 11 on the season. That builds an extremely reliable baseline for his Fantasy performances and he's also averaged 9.7 yards per pass attempt since his Week 5 bye.
3. Patrick Mahomes, Kansas City Chiefs: Mahomes leads the NFL with 11 interceptions this season but he had his second three-touchdown passing game in three weeks during a 30-21 loss to the Bills last week. This week he'll have a much better matchup against a Panthers defense that ranks last in the NFL in points allowed and 24th in passing yards allowed. See more top QBs here.
Top Week 12 Fantasy football RB rankings
Here's a look at SportsLine's top Week 12 Fantasy football RB picks:
1. Christian McCaffrey, San Francisco 49ers: The consensus top pick in 2024 Fantasy football drafts missed the first eight games of the season, much to the dismay of those who selected him. However, the 49ers have wasted no time getting him heavily involved in the offense upon his return, plying him with 42 touches in his first two games. He's turned those opportunities into 213 scrimmage yards and it feels like a matter of time before scoring chances start coming his way again after he scored 21 times last season.
2. De'Von Achane, Miami Dolphins: In the six games that Tua Tagovailoa has started for Miami this season, Achane has had at least 100 scrimmage yards and a touchdown in five of them. Now he'll match up with a New England defense that ranks 20th against the run this season and Dolphins running backs combined for 204 scrimmage yards and a touchdown against the Patriots earlier this season (Achane only played 11 snaps because of a concussion).
3. Jahmyr Gibbs, Detroit Lions: David Montgomery eats into Gibbs' scoring opportunities but there is more than enough to go around in this offense, with Gibbs producing 1,052 scrimmage yards and nine touchdowns in 10 games. He's averaging 6.0 yards per carry and now he'll take on a Colts defense that allowed Breece Hall to rack up 30 points in PPR leagues last week. See more top RBs here.
Top Week 12 Fantasy football WR rankings
Here's a look at SportsLine's top Week 12 Fantasy football WR picks:
1. Amon-Ra St. Brown, Detroit Lions: St. Brown had 11 catches for 161 yards and two touchdowns last week in a win over the Jaguars, either tying or setting new season-highs in all three categories. He's scored in eight consecutive games now and remains a source of reliable production on a weekly basis despite the fact that he's playing in the NFL's most loaded offense. The Colts rank 26th in the NFL in pass defense and will have their hands full with St. Brown in Week 12.
2. Justin Jefferson, Minnesota Vikings: Jefferson is averaging a staggering 97.3 yards per game during his five-year NFL career and he's been targeted at least eight times in eight consecutive games. He's had at least 100 yards receiving in four of his six career matchups with the Bears and Chicago just gave up 150 receiving yards to Christian Watson last week.
3. Nico Collins, Houston Texans: Collins was the NFL's receiving leader when he suffered a hamstring injury that sent him to IR and the Texans have been methodical in working him back into the mix, much to the chagrin of anybody who rosters him. He was activated off injured reserve in Week 10 but didn't dress and then only played 47% of snaps in his return to action last week. However, it was easy to see his big-play ability in limited work against the Cowboys, as he was targeted seven times and had four catches for 54 yards in addition to a 77-yard touchdown on a screen that was called back on the first play from scrimmage. See more top WRs here.
Top Week 12 Fantasy football TE rankings
Here's a look at SportsLine's top Week 12 Fantasy football TE picks:
1. Travis Kelce, Kansas City Chiefs: After being targeted at least nine times in five of his previous six games, Kelce was only thrown to four times and caught two passes for eight yards in a loss to the Bills. Andy Reid will know that he needs to rectify that moving forward and a juicy matchup against the Panthers should make a Mahomes-Kelce stack alluring in Week 12.
2. George Kittle, San Francisco 49ers: Kittle didn't play last week because of a hamstring injury but he's been the most productive tight end in the NFL this season when he's been on the field. You'll need to monitor his status but he should be an easy start if he's given the green light against Green Bay.
3. Brock Bowers, Las Vegas Raiders: The Georgia product must have been feeling the energy after his alma mater's big win over Tennessee, because he followed it up with 13 catches for 126 yards and a touchdown in Week 11. He was targeted 16 times and has now reached double-digits in targets four of his last six games. See more top TEs here.
Top Week 12 Fantasy football defense rankings
Here's a look at SportsLine's top three Week 12 Fantasy football D/ST picks:
1. Texans D/ST: The Texans did allow 324 passing yards to Cooper Rush and the Cowboys last week but they made up for it by attacking the backup relentlessly. They sacked him five times, intercepted him once and had a strip sack that eventually resulted in a touchdown. Now they'll take on the Titans and Will Levis, who have been prone to giving up defensive and special teams touchdowns (4) all season.
2. Steelers D/ST: After grinding out a win over the Ravens that gave them a stranglehold on the AFC North, the Steelers will visit the Browns on Thursday Night Football in Week 12. Cleveland hasn't run the ball for more than 80 yards in over a month and a one-dimensional offense should give T.J. Watt an opportunity to tee off on turnover-prone Jameis Winston.
3. Chiefs D/ST: The Panthers have won two games in a row and are coming off a bye week but they only threw for 284 passing yards in the process. They'll need a lot more than that for Bryce Young to win a duel with Mahomes and that will be tough to come by against a Kansas City defense that ranks eighth in points allowed and fifth in yards allowed. See more top D/ST here.
How to get Week 12 Fantasy football rankings
Now that you know who the top three at each position are, you'll want to see the full Week 12 Fantasy football rankings from SportsLine. The model has identified a stunner in the top 10 at tight end, and knowing who it is can give you a huge edge in your league. Head to SportsLine now to get Week 12 Fantasy football rankings.
So who should you target in your Week 12 Fantasy football rankings, and which surprising tight end could lead you to victory? Visit SportsLine now to get Week 12 Fantasy Football rankings for every single position, all from the model that has a history of making league-winning calls, and find out.