Etienne is slated to be the Jaguars' lead running back Sunday in Detroit with Tank Bigsby (ankle) ruled out for the contest.

Etienne acted as the primary RB for most of this past Sunday's loss to the Vikings after Tank Bigsby (ankle) made an early exit, turning 11 carries into 44 yards and his only target into a catch for minus-1 yard. Bigsby wasn't able to practice this week prior to Friday's declaration, and D'Ernest Johnson had a cap on his reps due to a hamstring issue. Considering the situation, Etienne could be in line for a large workload Sunday against a Lions defense that has given up seven TDs (tied for 21st) and 4.19 YPC (21st) to opposing running backs in nine games this season.

Bigsby (ankle) has been ruled out for Sunday's game at Detroit.

Bigsby injured his ankle during this past Sunday's loss to the Vikings. After Bigsby sat out practice Wednesday and Thursday, coach Doug Pederson told Demetrius Harvey of The Florida Times-Union that the running back was slated to get back on the field Friday, but that didn't come to pass. As a result, Bigsby won't be available Week 11, leaving the Jaguars backfield to Travis Etienne and D'Ernest Johnson (hamstring).

Williams (groin) has been ruled out for Sunday's game against Cleveland, Katherine Terrell of ESPN.com reports.

With Williams missing a third straight game, Jordan Mims again figures to serve as the No. 2 running back behind workhorse Alvin Kamara. Williams didn't practice at all this week, and his next chance to play will be on the other side of an upcoming Week 12 bye.

Jacobs (quadriceps) doesn't have an injury designation for Sunday's game at Chicago, Matt Schneidman of The Athletic reports.

The Packers limited Jacobs' practice reps coming out of a bye week but never gave any indication he was in danger of missing Sunday's game. Emanuel Wilson and Chris Brooks again will be the reserve options, as rookie running back MarShawn Lloyd was diagnosed Friday with appendicitis after missing the previous seven games due to a high-ankle sprain. Regardless, Jacobs is locked in as Green Bay's lead runner, averaging 17.6 carries for 84.7 yards per game, with three rushing TDs and a receiving TD in nine appearances.

Pollard (foot) doesn't have an injury designation for Sunday's game against the Vikings.

Pollard steadily increased his practice participation level throughout the week, capping Week 11 preparation with a full practice Friday following a DNP on Wednesday and a limited showing Thursday. He remains the lead back in Tennessee, though Pollard saw a decrease in usage following Tyjae Spears' return from a hamstring injury in Week 10 against the Chargers. Pollard got only nine carries in the 27-17 loss to Los Angeles after averaging 21.3 carries during Spears' three-game absence.

Lloyd (ankle) missed Friday's practice due to appendicitis and won't be available for Sunday's game at Chicago, Bill Huber of SI.com reports.

The Packers designated Lloyd on Monday to return from injured reserve, subsequently listing him as a limited practice participant Wednesday and Thursday due to ankle and hamstring injuries. It seems the newly reported hamstring injury isn't serious and wouldn't have prevented him from playing this week, but Lloyd now has an entirely different issue to deal with, after missing the past seven games with a high-ankle sprain. Packers coach Matt LaFleur said Friday that the team will talk to the league about a possible extension/exception for the 21-day window when a player is designated to return from IR, per Matt Schneidman of The Athletic. Reading between the lines, Lloyd is expected to miss at least two or three more weeks while recovering from surgery to address the appendicitis.

Jones (ribs) doesn't have an injury designation for Sunday's game at Tennessee, Tom Pelissero of NFL Network reports.

His availability isn't much of a surprise given that the returned to last week's 12-7 win at Jacksonville after he suffered the injury, taking four carries for 17 yards over the Vikings' final two drives. Jones will continue leading the Minnesota backfield, with Cam Akers subbing in for carries here and there.

Coach Andy Reid said Friday that Pacheco (ankle), who remains on injured reserve, won't play Sunday at Buffalo, Sam McDowell of The Kansas City Star reports.

Since the Chiefs designated Pacheco for return from IR on Tuesday, Pacheco put together limited practices Wednesday and Thursday, but he's still in his ramp-up period following the fractured fibula that he sustained Week 2 against the Bengals. In the meantime, Kareem Hunt will continue to pace Kansas City's backfield, while Samaje Perine and Carson Steele will be on hand for any RB reps that linger.

McNichols had three carries for five yards and one catch for one yard in a 26-18 loss to the Eagles on Thursday.

McNichols played 17 percent of snaps on offense, putting him well behind fellow Washington running backs Brian Robinson (53 percent) and Austin Ekeler (52 percent). McNichols had a slightly larger role the previous two weeks with Robinson sidelined by a hamstring injury, but even then the Commanders got Chris Rodriguez involved and kept it as a three-man backfield. McNichols is unlikely to see more than a handful of touches Week 12 against Dallas.

Coach Doug Pederson said Bigsby (ankle) will practice Friday, and he's optimistic the running back will play Sunday against the Lions, Demetrius Harvey of The Florida Times-Union reports.

"Optimistic," Pederson said Friday morning. "But today will be a big day for him." After missing practice Wednesday and Thursday, a Friday return gives Bigsby a chance to play Sunday in Detroit. If he's cleared to play, the Jaguars likely will continue to use a three-man backfield, consisting of Bigsby, Travis Etienne and D'Ernest Johnson, leaving none as upside fantasy plays against a tough Lions run defense.