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James Conner RB | ARI
Steelers' James Conner: Misses practice Wednesday
Conner (shoulder) didn't practice Wednesday, Teresa Varley of the Steelers' official site reports.
At this stage, Conner is looking iffy for Sunday's game against the Bengals. If he's forced to sit out the contest, Jaylen Samuels and Trey Edmunds would be next in line for touches in Pittsburgh's backfield touches, with Benny Snell and Kerrith Whyte candidates to work in reserve.
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Nick Bawden RB | HOU
Lions' Nick Bawden: Shut down for season
Bawden (knee) was placed on injured reserve Wednesday.
Bawden's season is over after he suffered a knee injury during this past Sunday's loss to the Cowboys. The second-year fullback averaged 12.7 offensive snaps per game this year, catching four of six targets for 17 yards. The Lions don't have another fullback on their active or practice rosters, so they may choose to fill the void via a free agent.
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Damien Harris RB | BUF
Patriots' Damien Harris: Limited at practice
Harris (hamstring) was limited at practice Wednesday, Mike Reiss of ESPN.com reports.
Harris sat out Sunday's win over the Eagles after being added to the Patriots' injury report two days ahead of the game. Even if the rookie running back is deemed healthy enough to play this weekend, he could still sit out against the Cowboys as a healthy inactive.
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Matt Breida RB | SF
49ers' Matt Breida: Still not practicing
Breida (ankle) will be held out of Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
In the midst of a 1-to-2-week recovery effort from a low-ankle sprain, Breida has yet to get on the practice field since suffering the injury Week 10. As long as Breida remains sidelined, Raheem Mostert will serve as the main change-of-pace option to Tevin Coleman out of the 49ers' backfield.
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Saquon Barkley RB | PHI
Giants' Saquon Barkley: Not on Wednesday's report
Barkley (shoulder) wasn't listed on the Giants' injury report Wednesday.
Coming off a Week 11 bye, Barkley is past the shoulder injury that he picked up in the Giants' last game Nov. 10 against the Jets. In the aftermath of his worst performance of the season -- 18 touches for 31 yards from scrimmage -- he relayed he has no desire to be rested at any point down the stretch, per Jordan Raanan of ESPN.com. With his health now intact, Barkley will turn his focus first to Sunday's matchup with the Bears, whose defense has allowed 129.7 yards from scrimmage per game and 11 touchdowns to running backs in 10 contests this season.
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Jordan Wilkins RB | CLE
Colts' Jordan Wilkins: Cleared to play
Wilkins (ankle) doesn't carry an injury designation into Thursday's game against the Texans.
With lead back Marlon Mack (hand) out indefinitely, Jonathan Williams and Wilkins are in line to serve as the top options in the Colts' Week 12 rushing attack, with Nyheim Hines slated to work in a change-of-pace role. It's the sort of timeshare that makes Wilkins a hit-or-miss fantasy proposition this week, but he's at least an option for those in need of running back due to injury or bye-week issues.
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James Conner RB | ARI
Steelers' James Conner: Iffy for Sunday
Adam Schefter of ESPN suggests that it "would be a mild upset" if Conner (shoulder) was available to play Sunday versus the Bengals.
In his return from a two-game absence for a Thursday night loss to the Browns in Week 11, Conner aggravated an AC joint injury in his right shoulder, which limited him to just 13 offensive snaps before he was pulled from the contest. If he's unable to suit up this weekend, added backfield work would be on tap for Jaylen Samuels, Trey Edmunds and Benny Snell.
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Matt Breida RB | SF
49ers' Matt Breida: Uncertain to practice Wednesday
Coach Kyle Shanahan admitted that he's unsure if Breida (ankle) will return to practice Wednesday, Matt Maiocco of NBC Sports Bay Area reports.
Breida missed the Week 11 win over the Cardinals after re-injuring the same ankle that hampered him earlier this season, so the team is clearly exercising caution in an effort to have the explosive back avoid a long-term setback. The 24-year-old was initially given a 1-to-2-week timetable to return from the low-ankle sprain, with Sunday's matchup with Green Bay representing the tail end of that range. Fantasy managers would ideally like to see Breida return to practice in some capacity this week, but it's unclear if that'll happen Wednesday.
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Myles Gaskin RB | SEA
Dolphins' Myles Gaskin: No yardage again Sunday
Gaskin ran once for no gain and was unable to bring in his only target during Sunday's 37-20 loss to the Bills.
Gaskin has now gained zero yards on both of his 2019 touches. It speaks a little to where the 2019 seventh-round pick is in his development that, despite a massive lack of production and depletion of depth at running back in Miami in recent weeks, Gaskin has logged just 12 offensive snaps over the past two games. The release of Mark Walton, who was already serving a suspension, might preserve whatever role the rookie develops until the end of the season, but as of now that role amounts to a touch or two a game for minimal yardage. Next up in Week 12 is a weak Browns run defense.
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Matt Dayes RB | NO
Matt Dayes: Works out in Chicago
Dayes (undisclosed) had a workout with the Bears on Tuesday, Aaron Wilson of the Houston Chronicle reports.
Dayes was waived off injured reserve by the Saints in September, but the workout indicates he's now healthy. The 2017 seventh-round pick has five career carries for 13 yards in 23 games between the Browns and 49ers.