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Jordan Wilkins RB | CLE
Colts' Jordan Wilkins: Leading rusher in Week 2 win
Wilkins rushed 10 times for 61 yards and caught both of his targets for three more in Sunday's 21-9 win over Washington.
Wilkins exited the game for a while with an ankle injury, but he was able to return and operated as Indianapolis' running back of choice with the team running out the clock in the fourth quarter. He was more effective than Marlon Mack (34 yards on 10 carries) and Nyheim Hines (seven yards and a touchdown on four carries), but the Colts' three-headed running back committee promises to leave fantasy owners frustrated throughout the season. That being said, Wilkins seems like the safest bet to lead the team in rushing yards most weeks.
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Dalvin Cook RB | DAL
Vikings' Dalvin Cook: Injures hamstring Sunday
Cook is questionable to return to Sunday's game at Green Bay due to a hamstring injury.
Cook got crunched on a tackle during overtime and remained on the ground for a spell before walking to the sideline under his own power. If he's unable to return, he'll finish the game with 90 yards from scrimmage on 13 touches. Latavius Murray will be the preferred running back option in Cook's stead.
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John Kelly RB | CLE
Rams' John Kelly: Inactive again
Kelly (coach's decision) is listed as inactive Sunday against the Cardinals.
Kelly has not appeared on the injury report during the regular season, but he nonetheless will miss his second consecutive game. While the 2018 sixth-round pick remains sidelined, Malcolm Brown will once again serve as the primary backup to Todd Gurley.
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Rob Kelley RB | NO
Redskins' Rob Kelley: Returns to game
Kelley (toe) returned to Sunday's game.
Kelley left Sunday's game with a toe injury but it looks as if he has been cleared to return. Kelley figures to slide back into his role as the team's No. 3 running back behind Adrian Peterson and Chris Thompson.
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Rob Kelley RB | NO
Redskins' Rob Kelley: Questionable to return to Sunday's game
Kelley left Sunday's game with a toe injury and is questionable to return, JP Finlay of NBC Sports Washington reports.
Kelley's questionable diagnosis suggests the injury might not keep him sidelined too long. The Redskins' No. 3 running back has been reduced to a limited role with the backfield emergence of Adrian Peterson, but Kelley is still regarded as a high-end reserve.
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Darrel Williams RB | NO
Chiefs' Darrel Williams: Inactive for Sunday's game
Williams (coach's decision) is inactive for Sunday's game at Pittsburgh, Adam Teicher of ESPN.com reports.
The specifics surrounding Williams' inactive status have yet to be released, but it's unlikely the LSU product would have had any major impact during Sunday's contest anyway. Slotted as the team's No. 4 running back, Williams will need to carve out a larger special teams role if he plans on keeping a roster spot for the entire 2018 season.
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Roc Thomas RB | JAC
Vikings' Roc Thomas: Won't suit up Sunday
Thomas (coach's decision) is listed as inactive for Sunday's game against the Packers.
Thomas was sidelined during Week 1 due to an ankle injury, but returned to full participation at practice Wednesday. He'll be a healthy scratch Sunday, however, while Dalvin Cook and Latavius Murray handle the work out of the backfield.
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Ronald Jones RB | DAL
Buccaneers' Ronald Jones II: Remains inactive Week 2
Jones (coach's decision) is inactive for Sunday's Week 2 tilt against the Eagles, Scott Smith of the Buccaneers' official site reports.
Jones will thus spend the first two games of his professional career on the sidelines, a result of both Peyton Barber's clear hold on the No. 1 running back role and Jones' own deficiencies in the preseason. The rookie's next chance to make his NFL debut comes in a Week 3 Monday night matchup against the Steelers.