Jacobs rushed six times for 44 yards and a touchdown while catching his only target for two yards in Sunday's 24-22 loss to the Bears.

Jacobs extended his touchdown streak to eight games with his 15th rushing touchdown of the season on a nine-yard run in the second quarter. That play capped Jacobs' first regular season in Green Bay, as Emanuel Wilson and Chris Brooks handled backfield duties the rest of the way. Jacobs rushed 301 times for 1,329 yards and 15 touchdowns while adding 36 catches for 342 yards and his first career receiving touchdown on 43 targets in the regular season. The seventh-seeded Packers will travel to Philadelphia in the wild-card round.

Mixon rushed the ball five times for 23 yards in Sunday's 23-14 win over the Titans. He added one reception on one target for five yards.

Mixon played one offensive possession with the rest of the Texans' starting unit and then gave way to Dameon Pierce as the team was locked into the fourth seed in the AFC. His five carries were enough for him to top 1,000 yards on the ground for the second consecutive campaign. While he's been held to fewer than 60 rushing yards in six of his last eight games, Mixon will play a key role in the Houston offense in a playoff matchup against either the Steelers or Chargers.

Guerendo won't return to Sunday's game at Arizona due to knee and ankle injuries.

Guerendo had his left leg twisted under him on his second carry of the game, and his teammates quickly motioned to the sideline for assistance. He eventually was carted off the field and ruled out not long after. With Guerendo unavailable, the 49ers will entrust the run game in Patrick Taylor and FB Kyle Juszczyk for the rest of their season finale.

Abanikanda (coach's decision) is inactive for Sunday's Week 18 matchup versus Arizona, Lindsey Pallares of the 49ers' official site reports.

Abanikanda will end the campaign in a familiar position, as he's been a healthy inactive on gameday throughout the season. The second-year running back didn't see any NFL action this year after getting into six games for the Jets in 2023. Abanikanda was claimed off waivers by San Francisco in early December but didn't get any looks despite the team's running-back room being decimated by injuries.

Hunt (coach's decision) is active for Sunday's game against the Broncos.

Hunt didn't miss any practice time this week, but with the Chiefs having already clinched the AFC's No. 1 seed heading to regular-season finale and planning to rest multiple key players on both sides of the ball, he had been listed as doubtful heading into Sunday. Though he'll be in uniform Sunday, Hunt may just make a ceremonial start, if he even plays at all. Normal starting running back Isiah Pacheco (ribs) is also sitting out Sunday, so the Chiefs are expected to lean on Samaje Perine and Carson Steele as their primary options out of the backfield.

Gainwell took reps with the first-team offense during pregame drills and appears in line to start Sunday's game against the Giants, Zach Berman of The Athletic reports.

With the Eagles having locked up the NFC's No. 2 seed, normal lead back Saquon Barkley will be resting in the regular-season finale, leaving Gainwell and Will Shipley as the team's available backfield options after Philadelphia elected not to elevate Tyrion Davis-Price from the practice squad for the second week in a row. Though he has worked as Barkley's top backup all season, Gainwell probably won't be tasked with handling a three-down workload, as the Eagles presumably want Gainwell to escape Week 18 healthy so that he can reprise his usual change-of-pace role in the wild-card round. With that in mind, it wouldn't be surprising if Shipley ends up seeing the larger share of snaps, though both he and Gainwell could struggle to produce with their opportunities while playing behind an offensive line mostly consisting of reserve players.

Hasty (coach's decision) is a healthy inactive for Sunday's game against the Bills.

Hasty sat out the Patriots' Week 16 loss in Buffalo due to an ankle injury, but he'll miss his first game of the season due to non-health-related reasons as he sits out the finale. He'll head into free agency this spring after concluding the 2024 campaign with 20 carries for 69 yards and 10 catches for 59 yards, and a touchdown on 12 targets over his 15 appearances.

Blackshear is expected to cede the start at running back to Miles Sanders (ankle) on Sunday in Atlanta, Darin Gantt of the Panthers' official site reports.

Blackshear got the first chance to lead the backfield in the wake of Chuba Hubbard (knee) landing on IR prior to Week 17, but despite handling a 77 percent snap share last Sunday at Tampa Bay, the former had eight carries for 20 yards and wasn't targeted. Now with Sanders off injured reserve, he's in line to swap in for Blackshear, which isn't much of a surprise considering his vast experience as a No. 1 back. Blackshear thus will be vying with Mike Boone for complementary reps behind Sanders on Sunday.

Shipley (concussion) is active for Sunday's game against the Giants.

Though he was listed as questionable heading into the weekend, Shipley put in full practices Thursday and Friday and was cleared by an independent neurologist at some point thereafter, allowing him to exit the NFL's five-step concussion protocol. With workhorse back Saquon Barkley (rest) sitting out the regular-season finale, Shipley should be primed for his heftiest snap count of the season, after taking the field for no more than 11 plays in any of his previous 15 games. Kenneth Gainwell may get the start for the Eagles, but he likely won't take on a Barkley-level workload as the team looks to preserve his health heading into the postseason. As the only other active running back, Shipley could thus be in store for plenty of volume on the ground and as a pass catcher, but he could struggle to produce while the Eagles are resting three of their starting linemen (offensive tackles Lane Johnson and Jordan Mailata, center Landon Dickerson).

Sanders (ankle) is listed as active and expected to start Sunday at Atlanta, Darin Gantt of the Panthers' official site reports.

In his first game action since he sprained his ankle Week 10 against the Giants, Sanders is in line to sit atop the backfield, what with both Chuba Hubbard (knee) and Jonathon Brooks (knee) on injured reserve and Velus Jones (coach's decision) inactive. Sanders will be vying with Raheem Blackshear (11 carries this season) and Mike Boone (nine) for touches Sunday. However, considering Sanders has 38 rushes and 21 receptions (on 26 targets) in 10 games on the campaign, he likely should be the top option among the trio.